Feasibility study of a disintegrin and metalloproteinase with thrombospondin motifs-1 as a diagnostic marker for hyperemesis gravidarum
Objective To study the feasibility of a disintegrin and metalloproteinase with thrombospondin motifs-1(ADAMTS-1)as a diagnostic marker for hyperemesis gravidarum(HG).Methods A total of 100 pregnant women admitted to Haikou People's Hospital from January 2019 to January 2022 were selected as the study subjects.Among them,49 patients diagnosed with hyperemesis gravidarum were the experimental group,and the other 51 healthy pregnant women were the control group.Peripheral serum ADAMTS-1 expression levels and general information and clinical characteristics,biochemical indicators of pregnant women were compared between the two groups,and the correlation between peripheral serum ADAMTS-1 expression levels and urinary ketosis was assessed.Results The levels of urinary ketones,blood glucose,glutamic-pyruvic transaminase,neutrophil count,plateletocrit,mean platelet volume,procalcitonin,platelet distribution width and ADAMTS-1 were higher in the experimental group than those in the control group,the differences were statistically significant(t=0.000,-2.490,-2.780,-3.024,-2.674,-2.978,-7.595,-19.812 and-11.596,respectively,P＜0.05).ADAMTS-1 was significantly positively correlated with urinary ketones,glutamic-pyruvic transaminase,neutrophil count,mean platelet volume,procalcitonin and platelet distribution width(r=0.58,0.22,0.21,0.22,0.51 and 0.66,respectively,P＜0.05),and negatively correlated with mean corpuscular volume and thyroid stimulating hormone(r=-0.23 and-0.32,respectively,P＜0.05).The area under the curve(AUC)of the receiver operating characteristic(ROC)curve of the subjects using peripheral ADAMTS-1 for diagnosis of hyperemesis gravidarum was 0.94(95％ CI=0.88-1.00,P＜0.05),the critical value of ADAMTS-1 was 9.48ng/mL,with a sensitivity of 85.71％and a specificity of 98.04％.Conclusion Serum ADAMTS-1 is significantly elevated in patients with HG and can be used as a valid biomarker for hyperemesis gravidarum.
万方数据
维普
