Relationship between serum 25(OH)D,AMH and pregnancy outcomes after first IVF/ICSI assisted pregnancy in patients with infertility
Objective To investigate the relationship between serum 25 hydroxyvitamin D[25(OH)D],anti-Muullerian hormone(AMH)and pregnancy outcome after the first in vitro fertilisation/intracytoplasmic monosperm injection-embryo transfer(IVF/ICSI-ET)assisted conception in infertility patients.Methods A total of 193 infertility patients admitted to the Reproductive Centre from January 2018 to December 2021 who underwent IVF/ICSI-ET treatment for the first time were selected,and they were divided into 122 cases in the pregnancy group and 71 cases in the non-pregnancy group according to whether they obtained clinical pregnancy or not.General information,controlled ovulation induction treatment and serum 25(OH)D and AMH levels were compared between the two groups.Pearson correlation analysis was used to investigate the correlation between serum 25(OH)D and AMH levels.Multifactorial logistic regression model was used to investigate the factors affecting clinical pregnancy.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum 25(OH)D and AMH for clinical pregnancy.Results There were no significant differences in age,body mass index(BMI),infertility years,infertility factors,basal follicle-stimulating hormone(FSH),basal luteinising hormone(LH),basal sinus follicle number,duration of gonadotropin(Gn)use,total amount of Gn used,oestradiol(E2)on the day of HCG,progesterone(P)on the day of HCG,mode of insemination,number of eggs obtained,egg maturation rate,and fertilisation rate between the gestational group and the non-pregnant group(all P＞0.05).The endometrial thickness,rate of high-quality embryos,proportion of transferred embryos of good quality,serum 25(OH)D and AMH levels were significantly higher in the pregnancy group than in the non-pregnancy group(t/x2=2.601-8.819,P＜0.05).Pearson correlation analysis showed that there was no significant correlation between the serum 25(OH)D level and the AMH level(r=0.186,P=0.225).Multifactorial logistic regression analysis showed that the quality of transferred embryos of good quality,25(OH)D,and AMH were the influencing factors of clinical pregnancy after IVF/ICSI-ET assisted conception in infertile patients(OR=1.556-2.004,P＜0.05).The area under the curve(AUC)for serum 25(OH)D and AMH to predict clinical pregnancy was 0.740 and 0.643,respectively(all P＜0.05).Conclusion Serum 25(OH)D and AMH levels are influential factors for clinical pregnancy in infertile patients after the first IVF/ICSI-ET assisted conception,and both of them can be used as reference indexes for predicting clinical pregnancy in this group of patients.
万方数据
维普
