The synergistic effect of ApoE gene polymorphism and high levels of Hcy on hypertension disorders of pregnancy
Objective In order to explore the synergistic effect of apolipoprotein E(ApoE)gene polymorphism and homocysteine(Hcy)on hypertension disorders of pregnancy.Methods A total of 200 pregnant women with gestational hypertension admitted to the people's hospital of Xinjiang Uygur Autonomous Region from January 2021 to December 2021 were selected as the study group,and 200 pregnant women with non-gestational hypertension during the same period were selected as the control group,and the ApoE gene polymorphism and Hcy levels of pregnant women in both groups were detected.Results The incidence of proteinuria,edema,fetal growth restriction and oligohydramnios in the study group was significantly higher than that in the control group(x2=10.751-34.783,P＜0.01).The serum Hcy level was significantly higher than that of control group(t=3.210,P＜0.05).The genotype frequencies of ε2ε3 and ε3ε3 genotype and the frequency of ε2 and ε3 allele in study group were significantly lower than those in control group,while the frequencies of ε3ε4 and ε4ε4 genotype and ε4 allele were significantly higher than those in control group(x2=4.624-32.172,P＜0.05).The genotype frequencies of ε2ε2 and ε2ε4 were slightly higher than those of the control group,but there was no significant difference(x2=1.309 and 0.069,respectively,P＞0.05).The Hcy levels of pregnant women with E3 and E4 AopE phenotype in the study group were significantly higher than those of the control group(t=4.009 and 2.609,respectively,P＜0.05),and the Hcy levels of pregnant women with E4 phenotype in the study group were significantly higher than those of E2 and E3(F=4.118,P＜0.05).The proportion of HHcy in pregnant women in the study group was significantly higher than that in the control grop in the E4 phenotype(x2=4.650,P＜0.05),but there was no significant difference in the HHcy level of the E2 and E3 phenotypes between the two groups(x2=3.678 and 3.432,respectively,P＞0.05).Conclusion There is a synergistic effect of ApoE gene polymorphism and high levels of Hcy in the pathogenesis of hypertensive disorders of pregnancy,and the interaction between ApoE gene ε4 allele and high Hcy level will increase the risk of hypertensive disorders of pregnancy.
apolipoprotein Ehomocysteinehypertension disorders of pregnancymorbidity risksynergistic effect
万方数据
维普
