Immunogenicity and safety of HPV vaccine in Asia population:a meta-analysis
Objective To evaluate immunogenicity and safety of human papillomavirus(HPV)vaccine in Asia population.Methods English databases such as PubMed,Embase,Web of Science,Clinical trails and Cochrane Library,and Chinese databases such as CNKI and Wan Fang Data were searched from their inception to April 2022 for randomized controlled trials(RCTs)about immunogenicity and safety of HPV vaccine.Using flexible collocation of subject words and free words,the literature were searched and screened according to inclusion and exclusion criteria.Then quality of the literature finally included was assessed and the data were extracted.A meta-analysis was conducted to merge the assessments through Review Manager 5.4 and Stata14.0 software.Results 16 RCTs were included,and 25 485 subjects were involved in these studies.Meta-analysis showed that HPV vaccine had good immunogenicity:the RR(relative risk)of HPV16 specific serum conversion rate merged effect value was 43.74(16.51-115.85)and that of HPV18 specific serum conversion rate merged effect value was 45.72(8.78-238.13).In safety of HPV vaccine,the risks of local adverse events caused by bivalent HPV vaccine(RR=1.52,95％ CI:1.34-1.73)and quadrivalent HPV vaccine(RR=1.38,95％CI:1.20-1.59)in the experimental group were higher than those in the control group.Also,the risks of systemic adverse events caused by bivalent HPV vaccine(RR=1.21,95％ CI:1.11-1.32)and quadrivalent HPV vaccine(RR=1.13,95％CI:0.99-1.30)in the experimental group were higher than those in the control group.Conclusion In these women population who had been inoculated HPV vaccine,the positive serum antibody conversion rate after inoculation of HPV vaccine for Asian population is higher than that in those women who hadn't been inoculated the HPV vaccine,suggesting that inoculation of HPV vaccine can improve individual's specific antibody level.However,the risks of local and systemic safety events caused by HPV vaccines in the experimental group are higher than those in the control group,suggesting that the safety problem of HPV vaccine should be emphasized.
human papillomavirusHPV vaccinemeta-analysisimmunogenicitysafety
万方数据
维普
