The expression and clinical significance of IGHG1 and TRIM 14 in cervical cancer tissue
Objective To investigate the expression and clinical significance of immunoglobulin G1 heavy chain constant region(IGHG1)and tripartite motif-containing 14(TRIM14)in cervical cancer tissue.Methods A total of 82 cervical cancer patients admitted to Baoding Maternal and Child Health Hospital from March 2019 to March 2020 were collected as study subjects,tumor tissues and adjacent tissues were taken during surgery,and they were separated into good prognosis group and poor prognosis group according to the 3-year follow-up.Immunohistochemical method was applied to detect the protein expression levels of IGHG1 and TRIM14 in cervical cancer tumor tissues and adjacent tissues.Multivariate Logistic regression was applied to analyze the factors affecting the prognosis of patients with cervical cancer.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of IGHG1 and TRIM14 protein expression levels in tumor tissue of cervical cancer patients on prognosis.Results Compared with adjacent tissues,the expression levels of IGHG1 and TRIM14 protein in cervical cancer tumor tissues were significantly higher(t=34.193 and 38.697,respectively,P＜0.05).The expression levels of IGHG1 and TRIM14 proteins were related to TNM staging,tumor differentiation degree,and lymph node metastasis in patients(t values ranged from 2.092 to 20.208,P＜0.05).Compared with the good prognosis group,the expression levels of IGHG1 and TRIM14 protein in poor prognosis group were obviously increased in the tumor tissue of cervical cancer patients(t=8.708 and 7.534,respectively,P＜0.05).The results of multivariate Logistic regression analysis showed that IGHG1 and TRIM14 protein were risk factors for poor prognosis in cervical cancer patients,the OR and 95％CI were 3.547(2.364-5.322)and 7.218(2.027-25.704),respectively.ROC analysis showed that the area under the curve of IGHG1 and TRIM14 combined to predict the prognosis of cervical cancer patients was 0.957,with a sensitivity and specificity of 78.00％and 98.25％,respectively.Conclusion High expression of IGHG1 and TRIM14 protein levels in tumor tissues of cervical cancer patients is related to the prognosis and may be a biomarker for evaluating the prognosis of cervical cancer.
cervical cancerimmunoglobulin G1 heavy chain constant regiontripartite motif-containing 14prognosis
万方数据
维普
