Application of pelvic ultrasound in ICPP diagnosis and short-term efficacy evaluation
Objective To investigate the value of pelvic ultrasound for the diagnosis of idiopathic central precocious puberty(ICPP)and the assessment of short-term efficacy after gonadotropin-releasing hormone analogue(GnRHa)treatment.Methods A total of 72 girls diagnosed with ICPP in Shaanxi Provincial People's Hospital from December 2019 to November 2022 were selected as the study group,of which 43 girls with ICPP who received GnRHa treatment were the observation group,and 64 girls who underwent health checkups in our hospital during the same period were selected as the control group,and all the girls were subjected to pelvic ultrasound examination.The differences in pelvic ultrasound parameters between the study group and the control group were compared,and the changes in hormone levels and pelvic ultrasound parameters in the observation group before and after treatment were compared;the correlation between the pelvic ultrasound parameters of the ICPP group and the results of the gonadotropin-releasing hormone(GnRH)stimulation test were investigated,and the diagnostic value of the pelvic ultrasound parameters of the single-parameter and the combination of the parameters were analysed by using the receiver operating characteristic(ROC)curves for the diagnosis of ICPP.Results The parameters of uterine long diameter,uterine transverse diameter,uterine anterior and posterior diameter,uterine body volume,uterine body/cervix,bilateral ovarian volume,bilateral follicle number,bilateral follicle diameter＞0.4cm and bilateral maximum follicle diameter were all significantly larger than those of the control group,and the differences were statistically significant(z=-7.971--3.327,respectively,all P＜0.05).The height,weight,pelvic ultrasound parameters and GnRH stimulation test results were all significantly lower in the observation group than those before treatment.parameters,and the difference was statistically significant(t/z=-9.491--0.881,respectively,P＜0.05),and the difference in BMI was not statistically significant(t=-1.844,P＞0.05).Correlation analysis showed that uterine long diameter,transverse uterine diameter,anterior-posterior uterine diameter,uterine corpus volume,bilateral ovarian volume and right maximal follicle diameter were significantly and positively correlated with the results of GnRH stimulation experiments(all P＜0.05).The area under the curve(AUC)for single-parameter diagnosis of ICPP was 0.607-0.897,and the AUC for multi-parameter combined diagnosis was 0.956,which had a higher diagnostic value.Conclusion ICPP affects the growth and development of girls,and GnRHa treatment can effectively improve the situation.Multi-parameter pelvic ultrasound has a higher diagnostic value for ICPP,which can provide an important basis for the diagnosis of ICPP and the evaluation of short-term efficacy.
pelvic ultrasoundidiopathic central precocious pubertydiagnosistherapeutic efficacy monitoring
万方数据
维普
