Objective To investigate the serum 25-hydroxyvitamin D levels in postmenopausal patients with osteoporosis and the value and significance of the clinical application of individualized vitamin D supplementation in patients.Methods Clinical data of postmenopausal women patients diagnosed with osteoporosis and treated with denosumab at The First Affiliated Hospital of Henan University of Science and Technology from June 2021 to June 2023 were retrospectively analyzed.A total of 86 patients who were first diagnosed with postmenopausal osteoporosis were enrolled in the study.The patients were divided into two groups according to the method of vitamin D supplementation,45 patients in the control group(fixed-dose group)and 41 patients in the observation group(individualized-dose group:supplementation was based on the patient's serum vitamin D level,with a target of ≥30 ng/mL).Bone density values and bone metabolism were observed and compared between the two groups.Results Before treatment,there were no significant differences in age,height,weight,serum 25(OH)D concentration,BMI,and bone mineral density of lumbar spine and femoral neck between the two groups(P＜0.05).After treatment,the levels of carboxy-terminal cross-linked telopeptide of β-type-1 collagen(β-CTX)and procollagen type 1 N-terminal prope-ptide(P1NP)in the observation group were reduced more significantly than those in the control group,and the level of 25 hydroxy-vitamin D was elevated higher than that of the control group,the difference was statistically significant(t=2.052,2.608,and 9.167,respectively,P＜0.05).The levels of bone mineral density in the femoral neck and lumbar vertebrae at the L2 segment of the observation group were higher than those of the control group,the difference was statistically significant(t=2.275 and 2.560,respectively,P＜0.05).Conclusions Vitamin D supplementation is associated with increased bone mineral density values in postmenopausal osteoporosis patients treated with denosumab,and individualized supplementation can achieve more benefits,which is worthy of clinical promotion.
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