Influence of pre-pregnancy and pregnancy related factors on children's neuropsychological development
Objective To explore the influence of pre-pregnancy and pregnancy related factors on children's neuropsychological development,and to provide scientific reference for promoting their neuropsychological development.Methods Based on the the Healthy Baby Cohort Study in Hubei province,pregnant women who were registered and had prenatal check-ups in the hospital from July 2016 to September 2018 were recruited,and 1 019 mother-child pairs were included as study subjects.The information of body mass index(BMI),age at conception,parity,occupation,educational level and delivery mode were collected by questionnaire The mental development index(MDI)and psychomotor development index(PDI)of the children were measured using the Bayley scales of infant development of China revision(BSID-CR)at the age of 2 years.BSID-CR scores＞79 were classified as normal group and ≤79 as abnormal group.Generalized linear model and logistic regression model were used to analyze the factors affecting children's neuropsychological development before and during pregnancy.Results Among 1 019 children,526(51.6％)were boys and 493(48.4％)were girls,86(8.4％)were in abnormal MDI group and 21(2.1％)were in abnormal PDI group.In MDI,the differences in the distribution of age at conception and pre-pregnancy BMI of mothers were statistically significant when comparing the normal and abnormal groups(x2=9.239 and 7.481,respectively,P＜0.05).The results of the generalised linear model analysis showed a negative association between age at conception and offspring MDI:compared with the age at conception of 24-35 years,the offspring of mothers ≥35 years old had a lower MDI of 6.913 points(95％CI:-10.177--3.650,P=0.001).There was a negative association between maternal pre-pregnancy BMI and offspring MDI:offspring whose mothers'pre-pregnancy BMI was overweight or obese had a 4.380 points lower MDI compared to those whose mothers'pre-pregnancy BMI was normal(95％CI:-8.004--0.755,P=0.018).There was a negative correlation between gestational weeks and offspring PDI:compared with gestational weeks of 37-42 weeks,offspring with gestational week＜37 weeks had a 6.910 points lower PDI(95％CI:-12.766--1.054,P=0.021).Multivariate logistic regression model analysis results showed that both age at conception ≥35 years(OR=1.749,95％CI:1.041-2.939,P=0.035)and pre-pregnancy BMI overweight OR obese(OR=1.765,95％CI:1.016-3.065,P=0.044)significantly increased the risk of offspring MDI abnormalities.Conclusion Mothers'advanced pregnancy age,pre-pregnancy overweight or obesity and preterm birth may be the high risk factors for abnormal neuropsychological development of offspring.Timely intervention of these factors is beneficial to promote children's intellectual development and improve population quality.
万方数据
维普
