首页|孤独症谱系障碍初筛阳性患儿康复训练后再评估的诊断研究

孤独症谱系障碍初筛阳性患儿康复训练后再评估的诊断研究

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目的 探讨孤独症谱系障碍(ASD)初筛阳性患儿康复训练后再评估的诊断情况及相关因素分析。方法 采用回顾性研究方法,选取2019年8月至2022年8月在聊城市人民医院儿童保健科行ASD初筛阳性患儿97例,将其分为≤24个月(12例)、>24~≤36个月(47例)、>36~≤72个月(38例)3个年龄段,再依据《美国精神障碍诊断统计手册第5版》(DSM-5)诊断标准将其分为ASD组(73例)与非ASD组(24例)。收集患儿初诊时儿童孤独症评定量表(CARS)或修订的幼儿孤独症筛查量表-后续修订版(M-CHAT-R/F)量表和盖泽尔发育诊断(Gesell)量表各能区得分,分析ASD初筛阳性患儿康复训练后再评估诊断情况及相关因素。结果 有75。3%的ASD初筛阳性患儿康复训练后再评估符合ASD诊断,其中男患儿占71。8%,女患儿占100。0%。ASD初筛阳性患儿康复训练后再评估,ASD诊断符合率随年龄段增长呈依次上升趋势(x2=10。032,P=0。002)。康复训练后再评估,ASD组患儿的Gesell量表中适应性、大运动、精细动作、语言、个人-社交能区得分均明显低于非ASD组,差异均有统计学意义(t值分别为-3。268、-1。970、-2。472、-3。205、-3。570,P<0。05)。康复训练后再评估,ASD诊断符合率与适应性(r=0。325)、大运动(r=0。229)、精细动作(r=0。241)、语言(r=0。286)、个人-社交(r=0。356)能区发育落后程度均呈正相关(P<0。05)。ASD组≤24个月患儿的M-CHAT-R/F量表得分明显低于非ASD组(t=-4。950,P<0。05),ASD组>24~≤36个月患儿的CARS量表和M-CHAT-R/F量表得分均明显高于非ASD组(t值分别为2。166、2。151,P<0。05),ASD组>36~≤72个月患儿的CARS量表得分也明显高于非ASD组(t=2。695,P<0。05)。对于>24个月的患儿,高CARS量表得分是康复训练后再评估诊断为ASD的危险因素(OR=1。367,95%CI:1。133~1。776,P<0。05),对于>24~≤36个月的患儿,高M-CHAT-R/F量表得分是康复训练后再评估诊断为ASD的危险因素(OR=1。623,95%CI:1。122~2。765,P<0。05)。结论 ASD初筛阳性患儿康复训练后再评估ASD诊断符合率较高,再评估ASD诊断符合率与患儿的性别、年龄、发育水平、初筛CARS量表或M-CHAT-R/F量表得分有关。
The diagnosis study of post-rehabilitation reevaluation of children with positive initial screening for autism spectrum disorders
Objective To explore the diagnosis and analysis of factors associated with post-rehabilitation reevaluation of children with positive initial screening for autism spectrum disorder(ASD).Methods A retrospective research analysis was used,97 cases children with positive initial screening for ASD were selected from August 2019 to August 2022 in the Department of Child Healthcare of Liaocheng People's Hospital,which were categorized into three age groups:≤24 months(12 cases),>24-≤36 months(47 cases),and>36-≤72 months(38 cases),and then,based on the diagnostic and statistical manual of mental disorders,fifth edition(DSM-5)of the United States,the children were divided into ASD group(73 cases)and non-ASD group(24 cases)according to the diagnostic criteria of the DSM-5.The Childhood Autism Rating Scale(CARS)or the Modified Childhood Autism Screening Scale-Revised/Further Revised(M-CHAT-R/F)scale and the Gesell Developmental Diagnostic Scale scores were collected at the time of the initial diagnosis of the children to analyze the diagnosis of the children with positive initial screening for ASD and the related factors after the reassessment of the diagnosis after the rehabilitation training.Results 75.3%children diagnosed as ASD after rehabilitation and the rate was 71.8%in male and 100%in female children respectively.In children with positive initial screening for ASD who were reevaluated after rehabilitation training,the compliance rate of ASD diagnosis increased sequentially with the age group(X2=10.032,P=0.002).Reevaluated after rehabilitation training,children in the ASD group had significantly lower scores on the Gesell scale in adaptive,gross motor,fine motor,language,and personal-social competence areas than those in the non-ASD group,and the differences were all statistically significant(t=-3.268,-1.970,-2.472,-3.205 and-3.570,respectively,P<0.05).Reassessed after rehabilitation,the ASD diagnostic compliance rate was positively correlated with the degree of developmental lag in adaptive(r=0.325),gross-motor(r=0.229),fine-motor(r=0.241),language(r=0.286),and personal-social(r=0.356),ability areas(P<0.05).The children in the ASD group ≤24 months had significantly lower M-CHAT-R/F scale scores were significantly lower than those of the non-ASD group(t=-4.950,P<0.05),and the CARS scale and M-CHAT-R/F scale scores of the ASD group were significantly higher than those of the non-ASD group for children>24-≤ 36 months of age(t=2.166 and 2.151,respectively,P<0.05).The CARS scale scores of children in the ASD group(>36-≤72 months)were significantly higher than those in the non-ASD group(t=2.695,P<0.05).Higher CARS score was a risk factor for diagnosing as ASD for children older than 24 months.[OR=1.367,95%CI:1.133-1776,P<0.05].Higher M-CHAT-R/F score was a risk factor for diagnosing as ASD for children between 24 to 36 months.(OR=1.623,95%CI:1.122-2.765,P<0.05).Conclusion Reassessment of ASD diagnostic compliance after rehabilitation of children with initial positive ASD screening is high,and reassessment of ASD diagnostic compliance is related to the child's gender,age,developmental level,and score on either the initial screening CARS scale or the M-CHAT-R/F scale.

autism spectrum disorderscreened positiverehabilitationdiagnosis

李沙沙、赵金霞、肖爽、朱丹、王翠、钱静

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聊城市人民医院儿童保健科,山东聊城 252000

孤独症谱系障碍 筛查阳性 康复训练 诊断

全民健康科技发展专项基金项目聊城市重点研发计划政策引导类项目

Z2020LSD0212022YDSF34

2024

中国妇幼健康研究
西安交通大学,中国疾病控制中心妇幼保健中心

中国妇幼健康研究

CSTPCD
影响因子:0.942
ISSN:1673-5293
年,卷(期):2024.35(2)
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