Effects of growth hormone combined with nutritional therapy on physical function indexes in children with idiopathic short stature
Objective To investigate the effect of recombinant growth hormone(rhGH)treatment with combined nutritional therapy on physical function indexes in children with idiopathic short stature(ISS).Methods A total of 102 children aged 5-12 years with ISS treated in Northwest Women's and Children's Hospital from January 2019 to January 2021 were selected as study subjects,and were divided into a control group(n=46)and an experimental group(n=56)according to the treatment plan.The control group received routine treatment with dietary and behavioral guidance.The experimental group was additionally injected with rhGH subcutaneously.The physical related indexes(height,weight,growth velocity and bone age),growth factors levels[insulin-like growth factor-1(IGF-1),insulin-like growth factor-binding protein-3(IGFBP-3)]and bone metabolism related indexes[serum 25-hydroxy-vitamin D3(25-OH-D3),bone-specific alkaline phosphatase(BAP)and osteocalcin(OC)]were compared before and after one year's treatment between the two groups.The incidences of adverse reactions were also compared between the two groups.Results After 1 year of treatment,both groups of patients showed significant increases in height,weight,growth velocity,and bone age compared to before treatment(t=-12.36--4.01,P＜0.05).The experimental group exhibited significantly higher increases in these parameters compared to the control group(t=5.75,5.59 and 23.07,P＜0.05),and the differences were statistically significant.The levels of 25-OH-D3,BAP,and OC in both groups were significantly higher than those before treatment(t=-15.68--3.49,P＜0.05),with the experimental group showing significantly higher levels compared to the control group(t=2.29,9.17 and 3.07,P＜0.05),and the differences were statistically significant.The levels of IGF-1 and IGFBP-3 in both groups were significantly higher than before treatment(t=-23.49--4.12,P＜0.05),with the experimental group exhibiting significantly higher levels compared to the control group(t=10.57 and 3.38,P＜0.05),and the differences were statistically significant.The incidence of adverse reactions in the experimental group(16.07％)was higher than the control group(4.35％),but the difference was not statistically significant(x2=3.61,P＞0.05).Conclusion rhGH combined with nutrition therapy in ISS children is effective and safe,and is worthy of clinical promotion.
growth hormoneidiopathic short staturebone metabolismgrowth factors
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维普
