Objective To study the effect of the interaction between total bile acid and glutamyl transpeptidase on neonatal hyperbilirubinemia.Methods A retrospective cohort study was used to select 267 neonates who were delivered in Huainan First People's Hospital from March 2020 to November 2022.According to whether the neonates had hyperbilirubinemia,they were divided into normal group(209 cases)and hyperbilirubinemia group(58 cases).The general data of the two groups were compared,and logistic regression was used to analyze the factors affecting the incidence of neonatal hyperbilirubinemia,and the interaction between total bile acid and glutamyl transpeptidase on neonatal hyperbilirubinemia.Results The proportion of neonatal infection and fetal distress was higher in hyperbilirubinemia group,and the levels of aspartate aminotransferase,C-reactive protein,alkaline phosphatase,total bile acids and glutamyl transpeptidase were higher,while the levels of direct bilirubin were lower,with statistical significance(c2/t value between 5.904 and 120.928,P＜0.05).Multivariate logistic regression analysis showed that high levels of alkaline phosphatase,aspartate aminotransferase,C-reactive protein,total bile acids and glutamyl transpeptidase as well as low levels of direct bilirubin,neonatal infection and fetal distress were risk factors influencing the incidence of neonatal hyperbilirubinemia(OR value between 1.364 and 1.964,P＜0.05);high levels of total bile acids and high glutamyl transpeptidase have both additive and multiplicative interactions.Conclusion The effect of total bile acids and glutamyl transpeptidase on neonatal hyperbilirubinemia exhibits a positively additive interaction.Clinically,the physiological levels of total bile acids and glutamyl transpeptidase should be monitored in time to ensure the health of newborns.
关键词
总胆汁酸/谷氨酰转肽酶/交互作用/高胆红素血症
Key words
total bile acids/glutamyl transpeptidase/interaction/hyperbilirubinemia
维普
万方数据