Correlation between gestational weight gain in women with gestational diabetes mellitus and adverse maternal and infant outcomes
Objective To examine the association between gestational weight gain(GWG)in pregnancy women with gestational diabetes mellitus(GDM)and adverse maternal and infant outcomes based on the GWG standards in China.Methods A total of 10 539 singleton pregnant women with GDM who registered for delivery from February 2019 to August 2022 in Chaoyang District,Beijing,were selected as the study subjects.Logistic regression analysis was used to analyze the association between GWG in GDM pregnant women and gestational hypertension,anemia,preeclampsia/eclampsia,premature rupture of membranes,cesarean section,low birth weight,macrosomia,small for gestational age(SGA)and large for gestational age(LGA).Results Among the 10 539 GDM pregnant women,35.53％had excessive GWG,20.56％had inadequate GWG,and 43.90％had appropriate GWG;42.49％of overweight individuals and 45.61％of obese individuals had excessive GWG.After adjusting for age,ethnicity,education level,occupation,parity,pre-pregnancy body mass index,and gestational age,the multivariable logistic regression analysis showed that excessive GWG was a risk factor for gestational hypertension,preeclampsia/eclampsia,cesarean section,macrosomia,and LGA(aOR=1.39-2.37,P＜0.05),and a protective factor for low birth weight and SGA(aOR=0.60 and 0.61,respectively,P＜0.01).In contrast,insufficient GWG was was a risk factor for low birth weight and SGA(aOR=1.81 and 1.38,respectively,P＜0.01),and a protective factor for premature rupture of membranes,cesarean section,and LGA(aOR=0.65,0.89 and 0.81,respectively,P＜0.05).No correlation was observed between GWG and comorbid anemia(P＞0.05).Conclusion Under the GWG standards for pregnancy in China,approximately 20％of GDM women had insufficient GWG,and about 40％of overweight and obese individuals had excessive GWG.Both excessive and inadequate GWG in GDM pregnant women increase the risk of adverse maternal and infant outcomes.Establishing specific GWG standards for the GDM population is meaningful for guiding and monitoring weight gain during pregnancy in women with GDM.
gestational diabetes mellitusgestational weight gainpregnancyadverse maternal and infant outcomes
万方数据
维普
