Clinical application value of risk genes for recurrent abortion
Recurrent spontaneous abortion(RSA)is a common adverse pregnancy outcome which affects 1％～5％of women of reproductive age.The etiology of RSA is complex,and the pathogenesis remains unclear,there are about 50％of RSA cases having unknown causes till now.RSA is caused by various exogenous and endogenous factors,in which genetic factors attract more attention in recent years.This review aims to explore risk genes of RSA,including thrombosis related genes such as F5,F2 and MTFHR,immune response related genes such as HLA-G,CTLA4 and IL-6,implantation and placental formation related genes such as VEGFA,NOS3 and MMP2,as well as hormone related genes such as ESR1,ESR2 and CYP1A1,and to explore association between genetic polymorphisms and risk of RSA occurrence.This study summarizes susceptible genes related to risk of RSA and explores clinical predictive values of genetic factors for risk of RSA,which contributes to assessment of influencing factors and pathogenesis of RSA,and lays foundation for subsequent establishment of precise polygenic risk scores(PRS)model.Moreover,it provides guidance for screening and prevention of RSA high-risk populations from genetic aspects.
recurrent spontaneous abortionrisk genegenetic polymorphismclinical application value
万方数据
维普
