The correlation between serum AMH,adropin and DHEAS expression with the onset of PCOS patients and its predictive value for treatment efficacy analysis
Objective To investigate the correlation between serum anti-Müllerian hormone(AMH),adropin(AD)and dehydroepiandrosterone sulphate(DHEAS)expression with the onset of polycystic ovary syndrome(PCOS)patients and its predictive value for treatment efficacy.Methods 62 PCOS patients who received metformin tablets combined with drospirenone and ethinylestradiol tablets(Ⅱ)treatment at our hospital from September 2020 to May 2022 were selected as the PCOS group,and 50 healthy individuals who underwent examinations at our hospital during the same period were selected as the control group.The serum AMH,AD and DHEAS levels of the two groups were measured to analyze their relationship with PCOS onset and the predictive value for treatment efficacy.Results The study found that in the PCOS group,the HOMA-insulin resistance index(HOMA-IR)and serum androstenedione(ASD),testosterone(T),luteinizing hormone(LH),AMH and DHEAS levels were significantly higher than those in the control group,and AD levels were significantly lower than those in the control group(t=7.808,12.701,13.121,16.717,11.659,17.476,and 25.391,respectively,all P＜0.05).Multivariate logistic regression analysis showed that HOMA-IR(OR=2.640,95％CI:2.439-9.284),AMH(OR=2.635,95％CI:1.458-4.763)and DHEAS(OR=1.087,95％CI:1.033-1.143)were independent risk factors for PCOS onset,while AD(OR=0.505,95％CI:0.286-0.891)was a protective factor(P＜0.05).Serum AMH and DHEAS levels in the effective treatment group were significantly lower than those in the ineffective group,and AD levels were significantly higher than those in the ineffective group(t=5.049,5.641,and 5.704,respectively,all P＜0.05).The receiver operating characteristic(ROC)curves analysis showed that the sensitivity,specificity and accuracy of predicting treatment efficacy in PCOS patients using serum AMH+AD+DHEAS levels[area under the curve(AUC)=0.909,95％CI=0.804-0.969]were higher than those of AMH alone(AUC=0.795,95％CI:0.668-0.889),AD alone(AUC=0.765,95％CI:0.635-0.866),and DHEAS(AUC=0.750,95％CI:0.619-0.854).Conclusions Combined detection of serum AMH,DHEAS,and AD in PCOS patients may provide evidence for predicting clinical efficacy and clarifying etiology.
polycystic ovary syndromeanti-Müllerian hormoneadropin proteindehydroepiandrosterone sulfatecurative effectpredictive value
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