Correlation analysis between cord blood CRP,PCT and IL-6 and brain injury in premature infants with intrauterine infection
Objective To investigate the correlation between cord blood C-reactive protein(CRP),procalcitonin(PCT),interleukin(IL)-6 levels and brain injury in premature infants with intrauterine infection.Methods 522 premature infants born from February 2020 to February 2023 at Yuncheng Central Hospital were selected as the research subjects.Cord blood CRP,PCT and IL-6 levels were measured.According to the presence of intrauterine infection(determined by placental histopathological examination,with the presence of more than 5 neutrophil infiltrations and diffuse aggregation indicating infection),the premature infants were divided into the infection group(n=47)and the non-infection group(n=475).Furthermore,cranial ultrasound and cranial magnetic resonance imaging(cMRI)were used to assess brain injury in premature infants.In the infection group,premature infants with brain injury confirmed by cranial ultrasound or cMRI were included in the brain injury group(23 cases),while those with normal findings on cranial ultrasound and cMRI were included in the non-brain injury group(24 cases).Multivariable logistic regression analysis was conducted to explore the relationship between cord blood CRP,PCT,IL-6,and brain injury in premature infants with intrauterine infection.Results Cord blood CRP,PCT and IL-6 levels in the infection group of premature infants were significantly higher than those in the non-infection group,with statistically significant differences observed between the two groups(t=31.139,55.033 and 16.719,respectively,P＜0.05).The incidence of brain injury in the infection group of premature infants(48.94％,23/47)was significantly higher than that in the non-infection group(15.79％,75/475),with a statistically significant difference between the two groups(x2=30.814,P＜0.05).Spearman correlation analysis results showed that brain injury in premature infants with intrauterine infection was positively correlated with cord blood CRP,PCT and IL-6 levels(r=0.300,0.295 and 0.308,respectively,P＜0.05).Multivariable logistic regression analysis revealed that cord blood CRP(OR=2.815,95％CI:1.521,5.209),PCT(OR=2.680,95％CI:1.022,7.031),and IL-6(OR=2.305,95％CI:1.082,4.911)were all factors influencing brain injury in premature infants with intrauterine infection(P＜0.05).Conclusion Brain injury in premature infants with intrauterine infection is positively correlated with cord blood CRP,PCT and IL-6 levels.Clinical monitoring of the three indicators can help to prevent brain injury in premature infants with intrauterine infection.
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