The impact analysis of isolated hypothyroidism during pregnancy on fetal head circumference development
Objective To explore and analyze the impact of isolated hypothyroidism during pregnancy on fetal head circumference(HC).Methods A total of 153 singleton pregnant women who underwent prenatal care at the Third Affiliated Hospital of Zhengzhou University from January to December 2020 were selected as study subjects.Those with gestational hypothyroidism detected during pregnancy but without intervention were classified into the non-intervention group(n=58),those who received oral levothyroxine tablets were classified into the intervention group(n=49),and those with normal thyroid function were classified into the normal group(n=46).The fetal HC development among the three groups was analyzed.Results There was a statistically significant difference in free thyroxine(FT4)levels among the three groups,and pairwise comparison showed that the FT4 level in the non-intervention group was lower than that in the intervention group and the normal group(H=104.973,P＜0.05).There was no statistically significant difference in thyroid stimulating hormone(TSH)levels among the three groups(P＞0.05).The difference in fetal HC development in the third trimester among the three groups was statistically significant,and pairwise comparison showed that the probability of fetal HC being smaller than gestational age was higher in the non-intervention group compared to the intervention group and the normal group(x2=11.781,P＜0.05).The differences in biparietal diameter(BPD)and HC values at 37 weeks of gestation among the three groups were statistically significant,and pairwise comparison showed that the BPD and HC values in the non-intervention group were smaller than those in the intervention group and the normal group(F=6.832,7.532,P＜0.05).There was no statistically significant difference in abdominal circumference(AC)and femur length(FL)values among the three groups(P＞0.05).The difference in HC at birth among the three groups was statistically significant,and pairwise comparison showed that the HC at birth in the non-intervention group was smaller than that in the intervention group and the normal group(F=3.332,P＜0.05).There was no statistically significant difference in birth length,birth body mass,and gestational age at birth among the three groups(P＞0.05).Conclusion Hypothyroidism during pregnancy has a negative effect on fetal HC development.Timely intervention for hypothyroidism is recommended to improve adverse prognosis.
isolated hypothyroidism during pregnancythyroid function during pregnancyfetal head circumferencefree thyroxine
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维普
