The impact of early personalized health management on the development of gestational diabetes mellitus in high-risk individuals
Objective To investigate the intervention effects of early personalized health management on preventing gestational diabetes mellitus(GDM)in high-risk individuals.Methods A total of 368 pregnant women with high risk factors of GDM who underwent prenatal examinations at the Xi'an Central Hospital from December 2021 to September 2022 were selected as the study subjects.Personalized health management measures were implemented from early pregnancy until completion of the oral glucose tolerance test(OGTT)between 24 to 28 weeks of gestation.The participants were divided into an intervention group(personalized health management group)comprising 201 cases and a control group(routine management group)comprising 167 cases.The gestational weight gain,results of the 75g OGTT and incidence of GDM of the two groups were observed and compared.Results In the intervention group,fasting blood glucose levels during OGTT were lower than those in the control group,showing statistical significance(t=2.894,P＜0.05).There were no statistically significant differences in blood glucose level in 1h and 2h of OGTT between the control and intervention groups(P＞0.05).The intervention group exhibited a lower incidence of GDM compared to the control group,with statistically significant(11.94％vs.19.76％,x2=4.261,P＜0.05).Stratified assessment based on different risk factors showed that in the high genetic risk population,the intervention group had a lower incidence of GDM compared to the control group,with statistically significant(x2=9.340,P＜0.05).In the low genetic risk population,there was no statistically significant difference between the intervention and control groups(P＞0.05).Maternal weight at delivery and gestational weight gain were both lower in the intervention group compared to the control group,with statistically significant(t=3.517 and 3.098,respectively,P＜0.05).Stratified assessment based on age showed statistically significant differences in the GDM incidence between the intervention group and the control groups across different age.The GDM incidence was higher in the 35-＜40 age group(x2=8.450,10.389,P＜0.05).Additionally,in the 30-＜35 age group,the GDM incidence was lower in the intervention group compared to the control group,with statistically significant differences(x2=6.187,P＜0.05).Conclusion Initiating personalized health management from early pregnancy can better control gestational weight gain,significantly enhance preventive effects for individuals at high risk of GDM,and reduce the incidence of GDM.Providing personalized health management to individuals with high genetic risk has positive clinical significant for reducing the incidence of GDM.
万方数据
维普
