Study on the effects of vitamin D deficiency on blood glucose,blood lipids,inflammatory indicators and growth and development of newborns
Objective To explore the effect of vitamin D deficiency on blood glucose and lipid levels,inflammatory indicators and growth and development of newborns.Methods 96 pregnant women with vitamin D deficiency in the second and third trimester of pregnancy who were treated in Mianyang Central Hospital from March 2020 to December 2022 were selected as the observation group,and 80 pregnant women with normal vitamin D levels in the second and third trimester of pregnancy who underwent examination in our hospital during the same period were selected as the control group.Both groups of pregnant women were followed until normal delivery.The levels of fasting plasma glucose(FPG),serum total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),serum interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)were compared between the two groups of newborns.The birth weight,body length,head circumference and ponderal index(PI)were measured.And the effects of vitamin D deficiency on blood glucose,blood lipids,inflammatory indicators and growth and development of newborns were analyzed.Results The levels of FPG,TC and LDL-C of newborns in the observation group were higher than those in the control group,with statistical significance(t=3.228,3.210 and 2.414,respectively,P＜0.05),while the difference in HDL-C levels between the two groups of newborns was not statistically significant(P＞0.05).The levels of hs-CRP and IL-6 in the observation group were significantly higher than those in the control group,with statistical significance(t=9.816 and 5.554,P＜0.05).The birth weight,body length and PI values of newborns in the observation group were lower than those in the control group,with statistical significance(t=10.001,6.580 and 3.852,respectively,P＜0.05).However,there was no significant difference in head circumference between the two groups of newborns(P＞0.05).Conclusion Maternal vitamin D deficiency during pregnancy may lead to elevated levels of the blood glucose and lipid concentrations of newborns,affecting the inflammatory indicators and the birth weight and body length of newborns.Therefore,appropriate supplementation should be considered for maternal vitamin D deficiency during pregnancy.
vitamin Dnewbornblood glucose and lipidinflammatory indicatorgrowth and development
万方数据
维普
