Predictive value of serum TSP-2 combined with PTX3 levels for postpartum hemorrhage
Objective To investigate the expression of thrombospondin-2(TSP-2)and pentraxin 3(PTX3)in the serum of pregnant women with postpartum hemorrhage(PPH)and predictive value for PPH.Methods 126 pregnant women who delivered in our hospital from September 2018 to September 2022 and experienced PPH were selected as the study group.Additionally,another 126 normal pregnant women who delivered at our hospital were chosen as the control group.The levels of serum TSP-2 and PTX3 were detected by enzyme-linked immunosorbent assay(ELISA),the predictive value of TSP-2 and PTX3 for maternal PPH was analyzed using receiver operating characteristic(ROC)curves.Multivariate logistic regression analysis was applied to analyze the influencing factors of PPH in pregnant women.Results The serum calcium levels(t=2.158)and adverse obstetric history(X2=8.966)in the study group were significantly higher than those in the control group(P＜0.05);TSP-2,PTX3,prothrombin time(PT),thrombin time(TT)and activated partial thromboplastin time(APTT)in the study group were significantly higher than in the control group(t values ranging from 2.339 to 8.414,P＜0.05),while the level of fibrinogen(FIB)was significantly lower than in the control group(t=2.413,P＜0.05).The area under curve(AUC)value for predicting maternal PPH was 0.729(95% CI:0.666-0.793)for TSP-2,0.732(95% CI:0.669-0.794)for PTX3,and 0.808(95% CI:0.754-0.863)for their combined prediction,which was superior to individual predictions(Zcombination-TSP-2=1.858,P=0.032;Zcombination-PTX3=1.787,P=0.037).Multivariate logistic regression analysis showed that TSP-2,PTX3,TT,FIB,PT,APTT and adverse obstetric history were the influencing factors for the occurrence of maternal PPH(OR values ranging from 1.131 to 2.249,P＜0.05).Conclusion TSP-2 and PTX3 both exhibit high expression in the serum of pregnant women with PPH.Their combination has a certain predictive value for the occurrence of PPH and can be an auxiliary marker for predicting PPH in pregnant women.
国家科技期刊平台
NSTL
万方数据
