The effect of endometrial thickness on live birth rates in intrauterine insemination
Objective To study the association between endometrial thickness and live birth rates in intrauterine insemination(IUI)assisted pregnancy.Methods A retrospective analysis was conducted on 8 739 assisted reproductive cycles performed on infertile patients who received artificial insemination by husband-intrauterine insemination(AIH-IUI)and met the inclusion criteria at the Reproductive Center of Northwest Women's and Children's Hospital from January 1,2014,to December 31,2021.Infertility patients were categorized into a live birth group(1 239 cases)and a non-live birth group(7 500 cases)based on whether they had a live birth following IUI treatment.Patients were categorized into five groups according to endometrial thickness measured during the last ultrasound before ovulation in the assisted reproductive cycles:3-6mm group(106 cases),7-9mm group(3 011 cases),10-12mm group(4 420 cases),13-15mm group(1 103 cases),≥16mm group(99 cases).The differences in early miscarriage rates,clinical pregnancy rates,and live birth rates among the five groups were compared.Multivariate logistic regression analysis was used to investigate the effect of endometrial thickness on IUI live birth rates after adjusting for the effects of female age and treatment regimen on IUI live birth rates.Results ① Pregnancy occurred in IUI assisted conception in patients when the endometrial thickness ranged from 3mm to ≥16mm.② When the endometrial thickness was 7-15mm(7-9mm group,10-12mm group,13-15mm group),the clinical pregnancy rates in IUI were higher than those in the 3-6mm group and ≥16mm group,but the difference was not statistically significant(x2=8.475,P=0.750).When the endometrial thickness was 7-15mm(7-9mm group,10-12mmgroup,13-15mm group),the live birth rates in IUI were higher than those in the 3-6mm group and ≥16mm group,but the difference was not statistically significant(x2=7.822,P=0.098).③ Multifactorial logistic regression analysis showed that compared with an endometrial thickness of 3-6mm,the live birth rates in IUI for patients with an endometrial thickness of 7-9mm,10-12mm,13-15mm,and ≥ 16mm were 2.0 times(OR=2.048,95％CI:0.982-4.271),1.8 times(OR=1.808,95％CI:0.855-3.826),1.8 times(OR=1.820,95％CI:0.824-4.021),and 1.0 times(OR=1.007,95％CI:0.345-3.208),that of the 3-6mm group,respectively.However,the increase in live birth rates did not reach statistical significance(P＞0.05).Conclusion The IUI live birth rates were lower when the endometrium is thin(＜7mm)or excessively thick(≥16mm)compared to normal endometrial thickness,but the difference was not statistically significant.Live births occurred across various endometrial thicknesses,and an endometrial thickness of 3-6mm is not an indicator to cancel IUI-assisted conception.
万方数据
维普
