Correlation analysis of serum magnesium levels and metabolic syndrome in endometrial cancer patients
Objective To investigate the relationship between serum magnesium levels and metabolic syndrome(MetS)and its related metabolic indicators in patients with endometrial cancer(EC).Methods General clinical data,serum magnesium levels and related metabolic indicators were collected from patients diagnosed with EC at the First Affiliated Hospital of Dalian Medical University from June 2016 to May 2021.Patients were divided into three groups based on different serum magnesium levels:hypomagnesemia group(＜0.7mmol/L)(18 cases),control group(0.7-1.1mmol/L)(244 cases)and hypermagnesemia group(＞1.1mmol/L)(29 cases).The serum magnesium levels and their relationships with general clinical characteristics and various metabolic indicators were compared and analyzed among the groups.Results There were statistically significant differences in the levels of serum magnesium among EC patients with and without type 2 diabetes,with and without menopause,and with waist circumference≥80 cm vs.＜80 cm(t=3.544,1.358 and 1.652,respectively,P＜0.05).There were also statistically significant differences in body mass index(BMI)and triglyceride(TG)levels among the groups with different serum magnesium levels(F=1.348 and 2.987,respectively,P＜0.05).Significant differences were found in the proportions of patients with type 2 diabetes,abnormal fasting plasma glucose(FPG)and MetS(x2=0.376,1.196 and 1.850,respectively,P＜0.05).Spearman correlation analysis revealed a significant negative correlation between serum magnesium ion levels and the number of MetS diagnostic criteria in EC patients(r=-0.201,P＜0.001).Pearson and Spearman correlation analyses showed that serum magnesium levels were negatively correlated with the incidence of MetS and excessive waist circumference of EC patients(r=-0.120,P=0.038;r=-0.151,P=0.009).After controlling for the confounding factors(menopause status and presence of type 2 diabetes),the negative correlations between serum magnesium levels and the incidence of MetS and excessive waist circumference of EC patients remained statistically significant(r=-0.101,P=0.013;r=-0.133,P=0.023).It was found that there was a negative correlation between the TG levels and serum magnesium levels(r=-0.109,P=0.025).Conclusion Serum magnesium concentration may be a sensitive indicator for assessing metabolic syndrome in patients with endometrial cancer.
万方数据
维普
