An observational study on the nutritional status of vitamin K in children aged 0-14 years in the northern of Beijing
Objective To observe the vitamin K nutritional status of children aged 0-14 years in the northern urban area of Beijing,providing a theoretical basis for the rational supplementation of vitamin K in children.Methods From November 2020 to March 2023,274 children from the northern urban area of Beijing(Changping District and northern Haidian District)who visited the children's health and growth development clinics at Beijing Jishuitan Hospital were selected.The levels of vitamin K1 and vitamin K2(MK-4,MK-7)were measured by high performance liquid chromatography-tandem mass spectrometry(LC-MS/MS);Bone density was measured using an ultrasonic bone densitometer;Vitamin K levels were analyzed and compared based on clinical data such as gender,age,season,height,weight,and body mass index(BMI).Results Among the 274 children,the median level of vitamin K1 was 0.39(0.25,0.72)ng/mL,with a low deficiency rate of 2.2％(6/274);The median level of vitamin MK-4 was 0.06(0.05,0.09)ng/mL,with a deficiency rate of 81.4％(223/274);The median level of MK-7 was 0.55(0.42,0.74)ng/mL,with no detected MK-7 deficiency.Vitamin K2 deficiency was mainly due to MK-4 deficiency.There was no statistically significant difference in serum vitamin MK-4 deficiency rate and serum MK-4 levels among different age groups(P＞0.05).There was no statistically significant difference in serum vitamin K1 levels among children in different seasons(P＞0.05);In summer,the average levels of serum vitamin MK-4 and MK-7 in children were the highest[0.07(0.05,0.09)ng/mL,0.76(0.55,1.07)ng/mL],while in winter they were the lowest[0.05(0.05,0.06)ng/mL,0.50(0.40,0.67)ng/mL].There was a statistically significant difference in serum vitamin MK-4 and MK-7 levels between different seasons(H=11.538 and 24.424,P＜0.05).There were no statistically significant difference in serum vitamin K1 and MK-7 levels between children with weight＞P10 and those with weight≤P10(P＞0.05);The serum vitamin MK-4 levels in children with a weight＞P10[0.06(0.06,0.09)ng/mL]were higher than those with a weight ≤P10[0.05(0.05,0.07)ng/mL],with a statistically significant difference(Z=-3.026,P＜0.05).No statistically significant differences were found in serum vitamin MK-7 levels among children with different BMIs(P＞0.05);There were statistically significant differences in serum vitamin K1 and MK-4 levels among children with different BMI(H=6.627 and 9.582,P＜0.05).There were no statistically significant difference in serum vitamin K1,MK-4,and MK-7 levels among children of different genders,ages,heights,and bone densities(P＞0.05).Conclusion In children aged 0-14 years in the northern urban area of Beijing,the deficiency rate of vitamin K2 is high,mainly due to MK-4 deficiency.Vitamin K2 levels show seasonal variation,and obese children have lower vitamin K levels than normal-weight children.
万方数据
维普
