Clinical symptoms of infant food allergy and analysis of serum specific immunoglobulin E detection results
Objective To investigate food allergens of infants with different allergic symptoms,so as to provide basis for prevention and treatment of food allergy in infants.Methods 849 infants with different allergic symptoms who received serum specific immunoglobulin E(sIgE)detection by immunoblotting method in Children's Health Care Center of Changsha Municipal Maternal and Child Health Hospital from January 2022 to December 2022 were selected.They were divided into＜6 month age group and＞6 month age group according to month age of the infant,and again they were divided into skin allergic symptom group(n=262),gastrointestinal allergic symptom group(n=113),malnutrition symptom group(n=56),respiratory allergic symptom group(n=58)and mixed allergic symptom group according to clinical allergic symptoms and disease history of the infant.The food allergens and positive distribution of sIgE were analyzed and compared among different age groups and between the two gender groups.Results Among 849 infants,the infants with skin allergic symptoms accounted for 30.9％(262/849),the infants with gastrointestinal allergic symptoms accounted for 13.3％(113/849),the infants with malnutrition symptoms accounted for 6.6％(56/849),the infants with respiratory allergic symptoms accounted for 6.8％(58/849)and the infants with mixed allergic symptoms accounted for 42.4％(360/849),of which,the male infants accounted for 57.8％(491/849),and the female infants accounted for 42.2％(358/849),and there was no significant difference between the two gender groups in distribution of allergic symptoms(P＞0.05).The infants aged＜6 months accounted for 23.8％(202/849)and the infants aged ≥6 month age accounted for 76.2％(647/849),there was a significant difference between the two age groups in distribution of allergic symptoms(x2=49.303,P＜0.001).Among 849 infants,the infants with positive detection result of sIgE for food allergens accounted for 51.7％(439/849),and the infants with negative detection result of sIgE for food allergens accounted for 48.3％(410/849),of them the male infants with positive sIgE detection result for food allergens accounted for 58.3％(256/439),and the female infants with positive detection result of sIgE for food allergens accounted for 41.7％(183/439),and there was no significant difference between the two gender groups in distribution of positive detection result of sIgE for food allergens(P＞0.05).The infants aged＜6 months with positive detection result of sIgE for food allergens accounted for 17.1％(75/439)and the infants aged ≥6 month with positive detection result of sIgE for food allergens accounted for 82.9％(364/439),there was a significant difference between the two age groups in distribution of positive detection result of sIgE for food allergens(x2=22.563,P＜0.001).In number of food allergens,there was a significant difference between the two age groups(Z=-4.376,P＜0.05),while there was no significant difference between the two gender groups(P＞0.05).In distributions of positive detection result of sIgE for food allergens and type of food allergens there were no significant differences among the infants with different allergic symptoms(both P＞0.05).Among common 12 food allergens,the sensitization degree of milk for positive sIgE detection result reached to grade 3 at most,and the sensitization degree of egg for positive sIgE detection result reached to grade 6 at most.The positive detection rate of sIgE for food allergens in the infants aged ≥6 months was higher than that in the infants aged＜6 months,but in the positive detection rate of sIgE for only milk,there was a significant difference among different age infants(x2=25.122,P＜0.001),while in the positive detection rate of sIgE for other 11 kinds of food allergens,there were no significant differences(all P＞0.05).Conclusion In early infancy,food allergic symptoms of the infants mainly present with skin allergic symptoms,and the food allergens are mainly milk and eggs.The detection of serum sIgE is of significance for diagnosing IgE mediated food allergy.However,the diagnosis of food allergy still needs to analyze and judge by combining other factors.
infantfood allergyserum specific immunoglobulin E detectionallergen
刘华、彭莉、曾宇东、王凭、刘燕、HU Meiyan
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长沙市妇幼保健院,湖南长沙 410011
Changsha Municipal Maternal and Child Health Hospital,Hunan Changsha 410011,China
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