Clinical value of CAL,S100A8 and S100A9 in the early diagnosis and condition judgment of neonatal sepsis
Objective To explore the clinical value of serum calprotectin(CAL),calcium-binding protein A8(S100A8),and calcium-binding protein A9(S100A9)in the early diagnosis and condition judgment of neonatal sepsis.Methods 118 cases of neonatal sepsis patients who admitted to our hospital from February 2020 to February 2023 were regarded as the study subjects.According to the severity of condition,they were divided into mild illness group(n=76)and severe illness group(n=42),and another 64 healthy newborns were selected as the control group during the same period.Enzyme-linked immunosorbent assay(ELISA)was applied to measure the levels of serum CAL,S100A8 and S100A9 in each group.The clinical data of neonatal sepsis patients with mild and severe conditions were compared.Spearman's method was applied to analyze the correlation between serum CAL,S100A8 and S100A9 levels and SNAP-Ⅱ scores.Multivariate Logistic regression analysis was conducted to identify the influencing factors for the occurrence of severe neonatal sepsis.Receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of serum CAL,S100A8 and S100A9 levels in early neonatal sepsis and the severity of the disease.Results Serum levels of CAL,S100A8 and S100A9 in control group,mild illness group and severe illness group were increased(F=54.894,64.181 and 67.572,respectively,P＜0.05).The area under the curve(AUC)of the combined diagnosis of serum CAL,S100A8 and S100A9 levels for neonatal sepsis was 0.956,with a sensitivity of 86.44％.Compared with the mild group,patients in the severe group had significantly higher Score for Neonatal Acute Physiology Ⅱ(SNAP-Ⅱ score),procalcitonin(PCT)and C-reactive protein(CRP)levels and significantly lower gestational age(t=23.398,6.239,7.783 and 4.457,respectively,P＜0.05).The levels of serum CAL,S100A8 and S100A9 were positively correlated with the SNAP-Ⅱ scores(rs=0.441,0.419 and 0.452,respectively,all P＜0.001).CAL,S100A8 and S100A9 were identified as risk factors for the occurrence of severe neonatal sepsis(OR=2.176,1.654 and 1.812,respectively,P＜0.05).The combined diagnosis of serum CAL,S100A8 and S100A9 levels for severe neonatal sepsis had an AUC of 0.961,with a sensitivity of 95.24％.Conclusion Serum levels of CAL,S100A8 and S100A9 have high clinical value for the early diagnosis and condition judgment of neonatal sepsis.
calprotectincalcium-binding protein A8calcium-binding protein A9early diagnosiscondition judgment
万方数据
维普
