Study on differences in vitamin D levels in children with tics and comorbid attention deficit hyperactivity disorder
Objective To investigate the relationship between serum vitamin D levels and the onset of tic disorder(TD)and comorbid attention deficit hyperactivity disorder(ADHD).Methods A total of 161 children diagnosed with TD at the pediatric outpatient department of Panzhihua Central Hospital from April 2021 to April 2023 were selected as study subjects.According to whether they had comorbid ADHD,they were divided into the simple TD group(n=103)and the TD+ADHD group(n=58).The differences in vitamin D levels between the two groups were compared.Results There was no significant difference in 25(OH)D levels between TD children of different genders(P＞0.05).TD children with a disease course of＞12 months had lower 25(OH)D levels than those with a disease course of≤12 months,with a statistically significant difference(t=3.02,P＜0.05).The proportion of TD children with insufficient serum 25(OH)D levels in the＞12 months group was higher than that in the≤12 months group,with a statistically significant difference(x2=6.88,P＜0.05).The 25(OH)D levels in children with moderate to severe TD were significantly lower than those in children with mild TD(t=3.64,P＜0.05).The proportion of children with insufficient and deficient serum 25(OH)D in the moderate to severe TD group was significantly higher than that in the mild TD group,with a statistically significant difference(x2=18.23,P＜0.05).There was no statistically significant difference in 25(OH)D levels between children with TD+ADHD and those with simple TD(P＞0.05).The proportion of children with insufficient and deficient serum 25(OH)D levels in the TD+ADHD group was higher than that in the simple TD group,with a statistically significant difference(x2=3.85,P＜0.01).Conclusion The degree of vitamin D deficiency is positively correlated with the severity,disease course,and risk of comorbid ADHD in TD.
万方数据
维普
