Study on the association between postpartum depression trajectories and vaginal flora changes
Objective To explore the relationship between postpartum depression(PPD)trajectories and changes in the vaginal flora in mothers.Methods From September 2021 to October 2022,102 postpartum women were selected as study participants in our hospital.Follow-ups were conducted at 2-3 days,6 weeks,3 months,and 6 months postpartum,and PPD was measured using the Edinburgh Postnatal Depression Scale(EPDS).Vaginal flora data were collected at 6 months postpartum.The study analyzed the trajectories of PPD changes within 6 months postpartum and their relationship with the vaginal flora.Results Two models were ultimately identified as the best models representing PPD trajectories:the first group(n=37,36.3％)was labeled as the increasing group,and the second group(n=65,63.7％)was labeled as the low-stable group.The increasing group showed a higher number of species(393.7±48.1 vs.368.2±65.8,t=4.36,P=0.013),richness(Chao1:429.7±55.0 vs.403.0±72.0,t=3.87,P=0.020)and biodiversity(Shannon index:5.25±0.46 vs.5.02±0.59,t=3.95,P=0.018)compared to the low-stable group.Compared with the low-stable group,the increasing group showed significantly lower levels of Bacteroides,Escherichia coli,Parabacteroides,and Prevotella(16.85％vs.22.69％,7.87％vs.10.20％,0.10％vs.0.31％,0.01％vs.0.11％,P＜0.05).However,Helicobacter(unidentified),Clostridium(unidentified),Helicobacter spp.,Erysipelotrichaceae(unidentified),Collinsella,and Lachnospiraceae were significantly higher(6.89％vs.4.58％,1.50％vs.0.77％,1.27％vs.0.76％,1.04％vs.0.66％,0.97％vs.0.36％,0.80％vs.0.54％,P＜0.05).The relative abundance of vaginal flora between the two groups of postpartum women showed significant differences(LDA score＞4,P＜0.05).Conclusion Women in the increasing group had a higher number,richness,and diversity of vaginal flora compared to the low-stable group,suggesting a correlation with the occurrence and progression of PPD.
vaginal florapostpartum depression16S rRNA gene sequencingtrajectory model
万方数据
维普
