Correlation between coagulation function of preterm infants in different gestational ages and the risk of intracranial hemorrhage
Objective To analyze the correlation between prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-Dimer(DD)levels and the risk of intracranial hemorrhage of preterm infants in different gestational ages within 24 hours.Methods A total of 132 premature infants admitted to Baoding Second Central Hospital from January 2018 to January 2023 were selected.They were divided into early preterm and late preterm groups based on gestational age at birth,and into hemorrhage and non-hemorrhage groups based on whether they experienced intracranial hemorrhage.General information and PT,APTT,DD,and FIB levels within 24 hours of birth were collected.The levels of PT,APTT,DD,and FIB within 24 hours were compared between preterm infants of different gestational ages and between those with and without intracranial hemorrhage.The risk factors for intracranial hemorrhage and the correlation between PT,APTT,DD,and FIB and gestational age were analyzed.The receiver operating characteristic(ROC)curve was used to assess the predictive value of each indicator for intracranial hemorrhage,and the area under the curve(AUC)was calculated.Results The birth weight of preterm infants in the early preterm group was lower than that in the late preterm group(t=5.254,P＜0.05).Pearson correlation analysis showed that PT,APTT,and DD were negatively correlated with gestational age,while FIB was positively correlated(r=-0.674,-0.588,-0.509 and 0.634,respectively,P＜0.001).The gestational age,birth weight,and FIB in the hemorrhage group were lower than those in the non-hemorrhage group,while the levels of PT,APTT,and DD were higher than those in the non-hemorrhage group(t=145.99,6.970,2.738,6.003,5.418 and 13.186,respectively,P＜0.05).Logistic regression analysis showed that gestational age(OR=1.406,95％CI:1.135-1.741),birth weight(OR=1.436,95％CI:1.051-1.961),FIB(OR=1.593,95％CI:1.220-2.080),PT(OR=1.430,95％CI:1.115-1.834),APTT(OR=1.319,95％CI:1.071-1.623),DD(OR=1.658,95％CI:1.075-2.557)were risk factors for intracranial hemorrhage in preterm infants(P＜0.05).The AUCs of PT,APTT,DD,and FIB for predicting intracranial hemorrhage in preterm infants were 0.750,0.774,0.798,and 0.884,respectively.Conclusion PT,APTT,DD,and FIB levels within 24 hours of birth differ among preterm infants of different gestational ages.Gestational age,birth weight,PT,APTT,DD,and FIB can serve as clinical indicators for assessing the risk of ICH in preterm infants.
gestational agepreterm infant24 hours after birthcoagulation functionintracranial hemorrhagerisk factor
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维普
