Application of tidal breathing pulmonary function examination combined with bronchodilation test in diagnosis of asthma in preschool children
Objective To explore application values of bronchodilation test(BDT)and tidal breathing flow volume curve(TBFV)in diagnosis of asthma in preschool children.Methods A total of 100 preschool children with asthma who admitted to Nanhai District Maternity and Child Health Hospital of Foshan City from January 2023 to January 2024 were selected as study subjects.According to disease progression,they were divided into study group A(acute attack stage,n=50)and study group B(chronic persistent stage,n=50).Another 50 healthy children who received regular physical examination were selected as control group.All the children received tidal breathing pulmonary function examination and BDT.The pulmonary function indexes of the children in the three groups and the positive rate of BDT between group A and group B were compared.Receiver operating characteristic(ROC)curve was used to evaluate diagnostic value of tidal breathing pulmonary function indexes for asthma in preschool children.The diagnostic efficacy of the combination of tidal breathing pulmonary function examination and BDT for asthma in preschool children was analyzed.Results The tidal volume per kilogram body weight(VT/kg),the peak-to-volume ratio[the time necessary to reach the peak expiratory flow in tidal breathing over the total expiratory time(TPTEF/TE)],peak-to-volume ratio[the volume necessary to reach the peak expiratory flow in tidal breathing over the total expiratory volume(VPEF/VE)]and the ratio of inspiration time over expiration time(Ti/Te)of the children were compared among the three groups,and the results shown that those in the study group A＜study group B＜control group(F=54.592,79.267,103.714 and 148.701 respectively,all P＜0.05).The total positive rate of BDT in 100 children with asthma was 44％,and the positive rate in the study group A was 62％and that in the study group B was 26％,showing that the positive rate in the study group A was higher than that in the study group B(x2=13.149,P＜0.05).ROC curve analysis showed that the areas under the curves(AUCs)of VPEF/VE,VT/kg,Ti/Te,TPTEF/TE and the combination of the four indexes above for diagnosing asthma in preschool children were 0.711,0.736,0.725,0.720 and 0.895 respectively.The sensitivity,specificity and accuracy of the combination of tidal breathing pulmonary function indexes and BDT for preschool asthma were higher than those of each single test(all P＜0.05).Conclusion In diagnosis of asthma in preschool children,the combination of tidal breathing pulmonary function and BDT has better diagnostic efficacy and high application value.
asthmatidal breathing pulmonary functionapplication valuebronchodilation test
万方数据
维普
