Expression and prognostic value of serum miR-18a and CXCL10 in patients with cervical cancer
Objective To investigate the expression of serum microRNA-18a(miR-18a)and CXC chemokine ligand 10(CXCL10)in patients with cervical cancer and their value in evaluating prognosis.Methods 112 patients with cervical cancer who were admitted to the Central War Zone General Hospital of the People's Liberation Army of China from January 2017 to December 2020 were retrospectively selected as the case group,and were divided into the survival group and the death group based on their 3-year survival status.In addition,83 patients with benign cervical tumors were included in the benign group.Serum levels of miR-18a and CXCL10 were measured in each group,and their correlation with cervical cancer clinical characteristics and patient survival prognosis was analyzed.Results The serum levels of miR-18a and CXCL10 in the cancer group were significantly higher than those in the benign group(t=13.819 and 17.524,respectively,P＜0.05).In the case group,the serum levels of miR-18a and CXCL10 were higher in patients with a depth of myometrial invasion＞1/2,TNM stage Ⅲ to Ⅳ,lymph node metastasis(t=2.260,4.118,3.851,2.141,3.104 and 2.699,respectively,P＜0.05).The incidence of TNM stage Ⅲ to Ⅳ and lymph node metastasis was significantly higher in the death group compared to the survival group(X2=17.903 and 36.107,respectively,P＜0.05),and the levels of serum miR-18a and CXCL10 in the death group were significantly higher than those in the survival group(t=6.359 and 5.373,respectively,P＜0.05).COX multivariate regression analysis showed that TNM grade,lymph node metastasis,and increased levels of miR-18a and CXCL10 were risk factors for poor prognosis in patients with cervical cancer(OR=5.778,5.150,1.220 and 1.020,respectively,P＜0.05).The area under the curve(AUC)for the combined detection of serum miR-18a and CXCL10 in predicting the survival prognosis of cervical cancer patients was 0.887(95％CI:0.827 to 0.948).Conclusion The levels of serum miR-18a and CXCL10 are significantly increased in patients with cervical cancer,and the serum levels of miR-18a and CXCL10 are closely related to tumor stage,lymph node metastasis and survival prognosis.
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