Analysis of the diagnostic and prognostic value of serum S100A8 and PD-L1 combined with ultrasound detection in endometrial cancer
Objective To investigate the diagnostic and prognostic value of combined serum S100 calcium binding protein A8(S100A8)and programmed death ligand 1(PD-L1)with ultrasound detection in endometrial cancer.Methods A total of 166 patients diagnosed with endometrial cancer in our hospital from April 2020 to April 2022 were selected as the cancer group,and they were classified according to the International Federation of Gynecology and Obstetrics(FIGO)standards into 48 cases of stageⅠ,52 cases of stage Ⅱ,42 cases of stage Ⅲ,and 24 cases of stage Ⅳ.166 patients diagnosed with endometrial hyperplasia in our hospital were selected as the control group.Enzyme-linked immunosorbent assay(ELISA)was used to measure serum levels of S100A8 and PD-L1,and transvaginal ultrasound was used to obtain blood flow spectra and measure blood flow parameters:pulsatility index(PI)and resistance index(RI).The diagnostic value of combined serum S100A8,PD-L1,and ultrasound parameters for endometrial cancer,as well as their prognostic predictive value,were analyzed using receiver operating characteristic(ROC)curve analysis.Results Compared with the control group,the levels of serum S100A8 and PD-L1 in the cancer group were significantly elevated(t=10.688 and 8.605,respectively,P＜0.001).Compared to stage Ⅰ,the levels of serum S100A8 and PD-L1 in stage Ⅱ,Ⅲ,and Ⅳ patients were significantly higher,and compared to stage Ⅱ,the levels of serum S100A8 and PD-L1 in stageⅣ were significantly elevated(P＜0.05).Additionally,the PI and RI values in the cancer group were significantly lower than those in the control group(t=7.183 and 6.799,respectively,P＜0.001).The area under the curve(AUC)for the combined diagnosis of endometrial cancer using serum S100A8,PD-L1,and ultrasound parameters was higher than the AUC for each individual marker(ZS100A8 vs.S100A8+PD-L1+PI+RI=6.472,P＜0.001;ZPD-L1 vs.S100A8+PD-L1+PI+RI=6.903,P＜0.001;ZPI vs.S100A8+PD-L1+PI+RI=7.072,P＜0.001;ZRI vs.S100A8+PD-L1+PI+RI=5.987,P＜0.001).Compared with the good prognosis group,the levels of S100A8 and PD-L1 in the poor prognosis group were significantly higher,while the levels of PI and RI were significantly lower(P＜0.001).The AUC for predicting the prognosis of endometrial cancer using the combined serum S100A8,PD-L1,and ultrasound parameters was higher than the AUC for each individual marker(Zs100A8 vs.S100A8+PD-L1+PI+RI=2.841,P=0.005;ZPD-L1 vs.S100A8+PD-L1+PI+RI=2.146,P=0.032;ZPI vs.S100A8+PD-L1+PI+RI=6.056,P＜0.001;ZRI vs.S100A8+PD-L1+PI+RI=4.370,P＜0.001).Conclusion Serum levels of S100A8 and PD-L1 are significantly elevated in patients with endometrial cancer,and the combination of serum S100A8,PD-L1,and ultrasound can enhance the diagnostic and prognostic values for endometrial cancer.
S100 calcium binding protein A8programmed death ligand 1ultrasoundendometrial cancerdiagnosisprognosis
万方数据
维普
