Objective To explore the influencing factors of neonatal pneumonia combined with multiple drug resistant organisms(MDRO)infection and provide a basis for the prevention and treatment of MDRO infection.Methods A total of 211 neonatal pneumonia patients admitted to the Children's Hospital Affiliated to Capital Institute of Pediatrics from June 2018 to June 2023 were selected as the research subjects.According to whether MDRO infection occurred within 3 days after admission,they were divided into infection group(n=40)and non-infection group(n=171).The electronic medical records of the two groups of children were consulted to obtain general and laboratory data.Univariate and multivariate Logistic regression analysis were used to study the influencing factors of neonatal pneumonia combined with MDRO infection.Results The results of univariate analysis showed that the incidence of premature birth,birth weight＜2 500g,parenteral nutrition,mechanical ventilation,combined use of ≥3 types of antibiotics,and use of antibiotics for＞7 days in the infection group was higher than that in the non-infection group,and the difference was statistically significant(x2=3.917-8.268,P＜0.05).The results of multivariate Logistic regression analysis showed that premature birth,birth weight＜2 500g,parenteral nutrition,mechanical ventilation,combined use of ≥3 types of antibiotics,and use of antibiotics for＞7 days were risk factors for neonatal pneumonia combined with MDRO infection(OR=4.305-9.010,P＜0.05).The predicted probability P of neonatal pneumonia with MDRO infection was obtained according to the Logistic regression model,and the receiver operating characteristic curve was drawn.The results showed that the area under the curve of the model for predicting neonatal pneumonia combined with MDRO infection was 0.817,with a 95％CI of 0.749 to 0.884,P＜0.001.Conclusion Premature birth,birth weight＜2 500g,parenteral nutrition,mechanical ventilation,combined use of ≥3 antibiotics,and use of antibiotics for＞7 days are risk factors for neonatal pneumonia combined with MDRO infection.The risk model constructed based on the above influencing factors has a good predictive value for neonatal pneumonia combined with MDRO infection,which can provide a basis for the prediction of MDRO infection.
关键词
新生儿/肺炎/多重耐药菌感染/影响因素/预测模型
Key words
neonate/pneumonia/multidrug-resistant bacterial infection/influencing factors/prediction model
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