Effect of cordycepin on chronic airway inflammation in a rat model of chronic asthma
Objective To investigate the potential inflammation suppression role of cordycepin on chronic airway inflammation in a rat model of chronic asthma.Methods Rats were randomized into control group, asthma group, cordycepin treatment groups (20 mg/kg and 50 mg/kg respectively), budesonide (BUD) treatment group and combination treatment group (BUD + cordycepin 50 mg/kg). After 8 weeks therapy on ovalbumin challenged asthma model, total cell counts and cell differentials in bronchoalveolar lavage fluid (BALF) and histologic examination of the lung tissues were performed. The levels of interleukin-4 (IL-4), IL-13, interferon-γ (IFN-γ) were measured by ABC-ELISA. Results The total cell counts and eosinophils in BALF of cordycepin group were significantly lower than asthma group ( P <0. 05), HE staining showed that compared with the treatment groups,there were a large number of inflammatory cells infiltration, heavier smooth muscle hypertrophy and mucous membrane hyperemia in the asthma group. The level of IL-4 and IL-13 in serum and BALF of 50 mg/kg cordycepin group, BUD group and combination group is significantly lower than the asthma group while IFN-γ were significantly higher ( P <0. 05). Conclusions Cordycepin may potentially inhabit the chronic airway inflammation of asthma by regulating T helper 1 ( Th1) and Th2 responses, and may have synergistic effect with corticosteroid.
NETL
NSTL
万方数据
维普
