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慢性阻塞性肺疾病气道黏液高分泌表观遗传学机制

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慢性阻塞性肺疾病是影响人类健康的重要疾病，气道黏液高分泌是慢性阻塞性肺疾病病理生理特征之一，影响着患者整体健康状况的评估，但具体分子机制仍不明确。近年来，大量研究发现表观遗传学通过多种机制改变基因表达，造成细胞功能异常，最终导致气道黏液分泌异常。本文就DNA甲基化、组蛋白修饰和非编码核糖核酸调节气道黏蛋白表达的研究进展作一综述。 Chronic obstructive pulmonary disease (COPD) is a major disease affecting human health。Chronic mucus hypersecretion is one of the pathophysiological characteristics of COPD， which affects the evaluation of patients′ overall health status， but the specific molecular mechanism is still unclear。In recent years， a large number of studies have found that epigenetics changes gene expression through a variety of mechanisms， resulting in abnormal cell function and ultimately abnormal airway mucus secretion。This artide reviews the advances in DNA methylation， histone modification and the regulation of airway mucin expression by non-coding RNA。
Epigenetic mechanism of airway mucus hypersecretion in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a major disease affecting human health.Chronic mucus hypersecretion is one of the pathophysiological characteristics of COPD, which affects the evaluation of patients′ overall health status, but the specific molecular mechanism is still unclear.In recent years, a large number of studies have found that epigenetics changes gene expression through a variety of mechanisms, resulting in abnormal cell function and ultimately abnormal airway mucus secretion.This artide reviews the advances in DNA methylation, histone modification and the regulation of airway mucin expression by non-coding RNA.

Pulmonary diseases, chronic obstructiveAirway mucus hypersecretionMucinEpigenetics

李华、李洁、丁琦、解宝珠、魏霞、薛芳

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1延安大学医学院临床医学系，延安　715700

2西安市第九医院呼吸与危重症医学科，西安　710054

肺疾病，慢性阻塞性 气道黏液高分泌 黏蛋白 表观遗传学

西安市创新能力强基计划项目西安市"科技"+"行动计划Science and Technology Innovation Ability Foundation Program in Xi'anProject of " Science and Technology" + " Action Plan" in Xi'an

21YXYJ0070XA2020-YXYJ-002621YXYJ0070XA2020-YXYJ-0026

2022

10.3760/cma.j.cn131368-20220128-00065

国际呼吸杂志
中华医学会 河北医科大学

国际呼吸杂志

CSTPCD
影响因子：0.55
ISSN：1673-436X
年,卷(期)：2022.42(8)
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