氧疗是呼吸衰竭患者常用且重要的呼吸治疗方法，但不恰当的氧疗可能对机体各器官造成不良反应，影响患者预后。过度氧疗和高氧血症的研究结局存在的矛盾源于对高氧血症的定义不统一，这是未来研究亟须解决的问题。目前研究结果显示临床维持生理状态下的动脉血氧分压(PaO2)，即80～100 mmHg(1 mmHg＝0.133 kPa)的氧疗目标是合适的。当需要高浓度氧疗时，需要关注吸入氧浓度对呼吸系统的影响；当机体处于重度或者极端高氧血症(PaO2>220 mmHg)时，会对机体的各脏器产生不利影响，临床上需要避免。真实世界大数据分析可能提供更多的信息以指导临床氧疗的实践。本文讨论过度氧疗导致的高氧血症对不同原因导致的急慢性呼吸衰竭和危重症患者的影响，希望对临床氧疗有所帮助。 Oxygen therapy is a common and vital respiratory management strategy for patients with respiratory failure.However, inappropriate oxygen therapy can induce adverse events in organs and influences the prognosis.Controversial findings in excessive oxygen therapy and hyperoxia are attributed to the inconsistent definition of hyperoxia, which needs to be solved in the future.Currently, the goal of oxygen therapy to maintain the partial pressure of oxygen in the arterial blood (PaO2) at 80-100 mmHg (1 mmHg=0.133 kPa) under physiological conditions.In cases of high-concentration oxygen therapy, the influence of the concentration of oxygen therapy on the respiratory system should be considered.Severe or extreme hyperoxia with PaO2>220 mmHg poses a negative influence on the human body, which should be prevented.Real-world big data analysis provides more references to guide the application of oxygen therapy.This article describes the influence of hyperoxia caused by an excessive oxygen therapy on patients with acute and chronic respiratory failure and critically ill patients caused by various causes, aiming to provide references for oxygen therapy.
Effect of an excessive oxygen therapy on patients with respiratory failure
Oxygen therapy is a common and vital respiratory management strategy for patients with respiratory failure.However, inappropriate oxygen therapy can induce adverse events in organs and influences the prognosis.Controversial findings in excessive oxygen therapy and hyperoxia are attributed to the inconsistent definition of hyperoxia, which needs to be solved in the future.Currently, the goal of oxygen therapy to maintain the partial pressure of oxygen in the arterial blood (PaO2) at 80-100 mmHg (1 mmHg=0.133 kPa) under physiological conditions.In cases of high-concentration oxygen therapy, the influence of the concentration of oxygen therapy on the respiratory system should be considered.Severe or extreme hyperoxia with PaO2>220 mmHg poses a negative influence on the human body, which should be prevented.Real-world big data analysis provides more references to guide the application of oxygen therapy.This article describes the influence of hyperoxia caused by an excessive oxygen therapy on patients with acute and chronic respiratory failure and critically ill patients caused by various causes, aiming to provide references for oxygen therapy.
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