Research advances on melatonin and respiratory diseases
王洁 1李龙 2刘胜菲 1陈凤 1段思琦
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作者信息
1. 兰州大学第一临床医学院，兰州 730000
2. 兰州大学第一医院呼吸与危重症医学科，兰州 730000
折叠
摘要
呼吸系统疾病的发生率逐年攀升，因此其预防、诊断和治疗也日益被重视。褪黑素是一种吲哚衍生激素，主要由松果体中的色氨酸合成，以响应各种生理刺激。褪黑素现已被证实对正常组织有多种影响，如抗氧化、抗炎、抗凋亡、抗癌、抗病毒和免疫调节等，是近年来研究的热点，因其具有良好的耐受性且不良反应小，在治疗多种呼吸系统疾病方面具有潜在的应用前景。本文就褪黑素的产生过程、作用机制，以及其在常见呼吸系统疾病中的具体作用作一简要概述，旨在为临床治疗提供思路。 The incidence of respiratory diseases annually increases.Therefore, the prevention, diagnosis and treatment of respiratory diseases have been gradually concerned.Melatonin (MT) is an indole-derived hormone synthesized primarily from tryptophan in the pineal gland in response to various physiological stimuli.The various effects of MT on normal tissues have been validated, such as antioxidant, anti-inflammatory, anti-apoptotic, anti-cancer, anti-viral and immunomodulatory properties.MT has been a research hotspot in recent years because of its good tolerance and less adverse events, presenting a potential application to the treatment of respiratory diseases.This article summarizes the production process, mechanism of action and specific role of MT in common respiratory diseases, thus providing references for the clinical treatment.
Abstract
The incidence of respiratory diseases annually increases.Therefore, the prevention, diagnosis and treatment of respiratory diseases have been gradually concerned.Melatonin (MT) is an indole-derived hormone synthesized primarily from tryptophan in the pineal gland in response to various physiological stimuli.The various effects of MT on normal tissues have been validated, such as antioxidant, anti-inflammatory, anti-apoptotic, anti-cancer, anti-viral and immunomodulatory properties.MT has been a research hotspot in recent years because of its good tolerance and less adverse events, presenting a potential application to the treatment of respiratory diseases.This article summarizes the production process, mechanism of action and specific role of MT in common respiratory diseases, thus providing references for the clinical treatment.
关键词
呼吸道疾病/氧化应激/褪黑素/核因子κB
Key words
Respiratory tract diseases/Oxidative stress/Melatonin/Nuclear factor-kappa B
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