辅助性T细胞17(Th17)和调节性T细胞(Treg)共同来自幼稚的CD4＋T淋巴细胞。研究显示，在气道炎症中Th17细胞对炎症有促进作用，而Treg细胞抑制自身免疫。Th17和Treg细胞比例失衡会促使气道炎症的出现。因此，维持Th17/Treg细胞免疫平衡在气道炎症的治疗上至关重要。同时，一些影响这些细胞产生和维持的调节因子也很重要，包括T细胞受体信号、共刺激信号、细胞因子信号等。本文就Th17/Treg细胞与这些调节因子之间的平衡的功能、作用及其在慢性阻塞性肺疾病和支气管哮喘中的临床意义进行阐述。 Helper T cell 17 (Th17) and Regulatory T cell (Treg) are derived from naive CD4+ T lymphocytes。In airway inflammation， Th17 cells can promote inflammation， while Treg cells can inhibit autoimmunity。The imbalance of Th17 and Treg cells can promote airway inflammation。Therefore， maintaining Th17/Treg cell immune balance is important in the treatment of airway inflammation。At the same time， some regulatory factors that affect the production and maintenance of these cells are also important， including T cell receptor signals， co-stimulatory signals， cytokine signals， etc。This article reviews the function and role of the Th17/Treg cells balance in chronic obstructive pulmonary disease and in bronchial asthma， so as to explore the clinical significance of the balance。
Research advances of Th17/Treg immune balance in the treatment of airway inflammation
Helper T cell 17 (Th17) and Regulatory T cell (Treg) are derived from naive CD4+ T lymphocytes.In airway inflammation, Th17 cells can promote inflammation, while Treg cells can inhibit autoimmunity.The imbalance of Th17 and Treg cells can promote airway inflammation.Therefore, maintaining Th17/Treg cell immune balance is important in the treatment of airway inflammation.At the same time, some regulatory factors that affect the production and maintenance of these cells are also important, including T cell receptor signals, co-stimulatory signals, cytokine signals, etc.This article reviews the function and role of the Th17/Treg cells balance in chronic obstructive pulmonary disease and in bronchial asthma, so as to explore the clinical significance of the balance.
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