游离脂肪酸受体(FFAR)是一类具有多功能性的G蛋白偶联受体，参与细胞内信号传导，调节细胞凋亡、炎症反应、免疫反应和能量代谢等生物学过程。近年来，国内外多项研究发现，FFAR在肺部疾病中发挥着重要作用，有望成为防治呼吸系统疾病的潜在研究靶点。本文对FFAR在哮喘、肺部感染、急性肺损伤、慢性阻塞性肺疾病、特发性肺纤维化等疾病发展中的作用及机制作一综述，以期为呼吸系统疾病的防控、干预提供新的方向。 Free fatty acid receptors (FFAR) are a class of multifunctional G protein-coupled receptors that are involved in intracellular signaling, regulating apoptosis, inflammatory response, immune response, energy metabolism, and other biological processes.In recent years, a large number of studies have found that FFAR play an important role in lung diseases.So FFAR are expected to become a potential target for preventing and treating respiratory diseases.This reviewaims to summarize the possible role of FFAR inasthma, lung infection, acute lung injury, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other pulmonary diseases.It is expected to open up new avenues for the control and treatment of these respiratory diseases.
Research progress of free fatty acid receptors in lung diseases
Free fatty acid receptors (FFAR) are a class of multifunctional G protein-coupled receptors that are involved in intracellular signaling, regulating apoptosis, inflammatory response, immune response, energy metabolism, and other biological processes.In recent years, a large number of studies have found that FFAR play an important role in lung diseases.So FFAR are expected to become a potential target for preventing and treating respiratory diseases.This reviewaims to summarize the possible role of FFAR inasthma, lung infection, acute lung injury, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other pulmonary diseases.It is expected to open up new avenues for the control and treatment of these respiratory diseases.
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