阻塞性睡眠呼吸暂停综合征(OSAS)是发病率较高、合并症较多的呼吸系统疾病，由于肥胖和老龄化的增加，OSAS的患病率也在持续攀升。OSAS患者在睡眠过程中发生循环性缺氧-复氧事件会导致系统性炎症并导致肺动脉高压，但OSAS导致肺动脉压升高的机制尚不明确。本文综述了OSAS通过损伤肺血管内皮细胞糖萼导致肺动脉高压的可能机制，为应用药物抑制血管内皮细胞糖萼的损伤从而延缓肺动脉高压的发生和发展提供思路。 Obstructive sleep apnea syndrome (OSAS) is a respiratory disease with high incidence rate and more complications。Due to the increase of obesity and aging， the prevalence of OSAS continues to rise。The occurrence of cyclic hypoxia reoxygenation events during sleep in OSAS patients can lead to systemic inflammation and pulmonary hypertension， but the mechanism is not yet clear。This article reviews the possible mechanism of OSAS causing pulmonary arterial hypertension by damaging the glycocalyx of pulmonary vascular endothelial cells， providing ideas for the application of drugs to inhibit the damage of glycocalyx of vascular endothelial cells， so as to delay the occurrence and development of pulmonary arterial hypertension。
Research progress on endothelial cell glycocalyx damage and its harm in obstructive sleep apnea syndrome
Obstructive sleep apnea syndrome (OSAS) is a respiratory disease with high incidence rate and more complications.Due to the increase of obesity and aging, the prevalence of OSAS continues to rise.The occurrence of cyclic hypoxia reoxygenation events during sleep in OSAS patients can lead to systemic inflammation and pulmonary hypertension, but the mechanism is not yet clear.This article reviews the possible mechanism of OSAS causing pulmonary arterial hypertension by damaging the glycocalyx of pulmonary vascular endothelial cells, providing ideas for the application of drugs to inhibit the damage of glycocalyx of vascular endothelial cells, so as to delay the occurrence and development of pulmonary arterial hypertension.
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