多囊卵巢综合征中翻译后修饰的研究进展
Research Progress on Post-Translational Modification in Polycystic Ovary Syndrome
刘一燃 1冯睿芝 2钱云1
作者信息
- 1. 210028 南京医科大学第二附属医院生殖医学中心
- 2. 南京医科大学生殖医学与子代健康全国重点实验室
- 折叠
摘要
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是常见的女性内分泌紊乱性疾病之一,其具体发病机制尚不明确,可能受到表观遗传和环境等多种因素的影响.近年来,PCOS的患病率持续增加,导致患者的生活质量出现不同程度地下降,因此积极探索新的治疗方案十分必要.蛋白质翻译后修饰(post-translational modification,PTM)是调节蛋白质功能的重要方式,研究发现磷酸化修饰与PCOS胰岛素抵抗密切相关,乙酰化修饰的研究多聚焦于PCOS卵母细胞质量方面,而甲基化修饰则与PCOS脂质代谢异常密不可分.探索PTM在PCOS发生、发展中的作用可能有助于为疾病的靶向治疗提供新思路.
Abstract
Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorders in women,but its pathogenesis is unknown.Current researches suggested that the disease may be influenced by a variety of factors,including epigenetic and environmental factors.In recent years,the incidence of PCOS has been increasing,leading to a decline in the quality of life of patients.Therefore,it is necessary to actively explore new treatments.Post-translational modification(PTM)is an important way to regulate protein function.Most studies have found that phosphorylation is closely related to insulin resistance of PCOS,acetylation is mainly focused on the quality of PCOS oocytes,and methylation is closely related to PCOS lipid metabolism.Exploring the role of PTM in the occurrence and development of PCOS may provide new ideas for targeted treatment of this disease.
关键词
多囊卵巢综合征/蛋白质加工,转译后/磷酰化/乙酰化作用/甲基化/泛素化Key words
Polycystic ovary syndrome/Protein processing,post-translational/Phosphorylation/Acetylation/Methylation/Ubiquitination引用本文复制引用
基金项目
国家自然科学基金(81971451)
江苏省"双创团队"项目(JSSCTD202144)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据