肠道菌群及肠道代谢物与多囊卵巢综合征的关系
The Relationship between Intestinal Flora,Intestinal Metabolites and Polycystic Ovary Syndrome
周昕玥 1李宁 1魏林飞 1张学红1
作者信息
- 1. 730000 兰州大学第一临床医学院,兰州大学第一医院生殖医学中心
- 折叠
摘要
人体肠道微生物丰富多样,其中肠道菌群可通过脑-肠轴途径影响宿主代谢、免疫等多个过程,进而与多种疾病的发生发展相关.多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者肠道菌群的改变与其胰岛素抵抗、高雄激素血症、慢性炎症、代谢综合征等临床特征及并发症相关.近年研究表明肠道菌群也可能通过胆汁酸、短链脂肪酸、神经酰胺、三甲胺衍生物等肠道代谢产物影响PCOS的发病及病理过程.此外,也有部分研究探讨了应用粪便微生物群移植、补充益生菌和合生元等调节肠道菌群,以期为改善PCOS临床表现及相关并发症提供理论基础.
Abstract
Human gut microbiota is rich and diverse,among which gut microbiota can affect host metabolism,immunity and other processes through the brain-gut axis pathway,and then is related to the occurrence and development of a variety of diseases.The changes of intestinal flora in patients with polycystic ovary syndrome(PCOS)are related to clinical features and complications such as insulin resistance,hyperandrogenism,chronic inflammation and metabolic syndrome.Recent studies have shown that intestinal flora may also affect the pathogenesis and pathological process of PCOS through intestinal metabolites such as bile acids,short-chain fatty acids,ceramides and trimethylamine derivatives.In addition,some studies have explored the application of fecal microbiota transplantation,supplementation of probiotics and synbiotics to regulate intestinal flora,in order to provide a theoretical basis for improving the clinical manifestations and related complications of PCOS.
关键词
多囊卵巢综合征/胃肠道微生物组/治疗/代谢疾病/肠道代谢物Key words
Polycystic ovary syndrome/Gastrointestinal microbiome/Therapy/Metabolic diseases/Intestinal metabolites引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据