The Relationship between Intestinal Flora,Intestinal Metabolites and Polycystic Ovary Syndrome
Human gut microbiota is rich and diverse,among which gut microbiota can affect host metabolism,immunity and other processes through the brain-gut axis pathway,and then is related to the occurrence and development of a variety of diseases.The changes of intestinal flora in patients with polycystic ovary syndrome(PCOS)are related to clinical features and complications such as insulin resistance,hyperandrogenism,chronic inflammation and metabolic syndrome.Recent studies have shown that intestinal flora may also affect the pathogenesis and pathological process of PCOS through intestinal metabolites such as bile acids,short-chain fatty acids,ceramides and trimethylamine derivatives.In addition,some studies have explored the application of fecal microbiota transplantation,supplementation of probiotics and synbiotics to regulate intestinal flora,in order to provide a theoretical basis for improving the clinical manifestations and related complications of PCOS.
国家科技期刊平台
NSTL
万方数据
维普
