Application Progress of Progestin-Primed Ovarian Stimulation
In assisted reproductive technology,it is very important to prevent the premature endogenous luteinizing hormone(LH)peak in process of controlled ovarian stimulation.Traditional controlled ovarian stimulation protocols with gonadotropin-releasing hormone(GnRH)analogues(GnRH agonists or antagonists)to inhibit the level of endogenous LH have many disadvantages such as high cost and inconvenient use.Progestin-primed ovarian stimulation(PPOS)protocol has been proved to achieve good clinical outcomes in various populations by the negative feedback effect of exogenous progesterone on pituitary gland to inhibit LH level,and its offspring safety has also been preliminarily confirmed.In this paper,the mechanism of PPOS,application of different exogenous progesterone drugs,application effects of different populations and offspring safety of PPOS were reviewed.
国家科技期刊平台
NSTL
万方数据
维普
