Research Progress of Cuproptosis in Gynecologic Malignant Tumor
Copper ion as an important coenzyme participates in a wide range of metabolic processes,including aerobic respiration,peptide amidation,iron transport,superoxide dismutase and extracellular matrix biosynthesis.Copper homeostasis is an important mechanism to maintain cell activity.Cuproptosis is a form of cell death caused by the accumulation of copper ions,which is characterized by the imbalance of copper homeostasis,the accumulation of copper in cells,the selective disturbance of tricarboxylic acid cycle,the aggregation of fatty acylated mitochondrial enzymes and the loss of iron-sulfur protein,the protein stress of mitochondria,the cell membrane cracking,and finally the cell death.Gynecological malignant tumors are important causes of cancer death in women.It is found that cuproptosis is closely related to the occurrence,development,prognosis and drug resistance of gynecological malignant tumors.Some cuproptosis regulators can inhibit tumor metastasis and recurrence by inhibiting angiogenesis and regulating drug resistance of cancer cells.Therefore,cuproptosis is a valuable research direction for the treatment of gynecological malignant tumors.
国家科技期刊平台
NSTL
万方数据
维普
