The pathogenesis of empty follicle syndrome has not been clarified.More and more research has focused on the genetic factors of empty follicle syndrome,especially the genes involved in regulating oocyte development.Zona pellucida glycoprotein 1(ZP1)is a key component of the structural integrity of the zona pellucida matrix.Structural and functional defects of zona pellucida due to the mutations of ZP1 gene often lead to the impaired oocyte maturation and the increased fragility,which may lead to the repeated oocyte retrieval failures.Various mutations of ZP1 gene that cause empty follicle syndrome phenotypes have been identified.In this paper,we reviewed the action and mechanism of ZP1 gene mutations at different sites in causing the empty follicle syndrome phenotype.
维普
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