The Role of LncRNA as CeRNA in Polycystic Ovary Syndrome
Polycystic ovary syndrome(PCOS)is a common female reproductive endocrine disorder that is related with various factors including epigenetic and environment.Long non-coding RNA(lncRNA),with more than 200 nucleotides,are a kind of RNA molecules that do not code proteins.LncRNA can affect the expression of gene through epigenetic modification,transcriptional and post-transcriptional regulation.As a kind of competing endogenous RNA(ceRNA),lncRNA can affect the expression of target gene by competitively binding microRNA(miRNA).As a new regulatory mechanism,it can play an important role in many biological processes such as cell proliferation and differentiation,inflammatory response and immune response,which is closely related to many diseases.The ceRNA hypothesis also provides a further understanding of the mechanism of PCOS.Recently,the studies of lncRNA in PCOS significantly increased.The lncRNA differentially expressed in PCOS can involve as ceRNA in ovarian granulosa cell proliferation,oocyte maturation as well as hormone synthesis,and play an potential role in the development of PCOS.In this review,we summarize the roles of lncRNA as ceRNA in the occurrence and development of PCOS.
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