Perimenopausal period is a special period in the life process of the female.During this period,the reproductive function of women declines and the levels of hormones fluctuate,leading to a series of clinical symptoms.Sleep disorder is one of the common symptoms.The factors and pathogenesis of perimenopausal sleep disorders are mainly related to hormonal changes,vasomotor symptoms and neurotransmitter unbalance.It is also related to anxiety and depression,emotional disorder,sleep-wake cycle,down-regulation of melatonin,apnea and hypopnea,restless leg syndrome,etc.Aging itself and metabolic problems also play a role.In this article,we discuss the related factors and pathogenesis of perimenopausal sleep disorders from the different perspectives.
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