miR-202在生殖调控中的研究进展
Advancements of MiR-202 in Reproductive Modulation
梁越 1董杰 1肖西峰 1王晓红1
作者信息
- 1. 710000 西安,空军军医大学唐都医院生殖医学中心
- 折叠
摘要
微小RNA(microRNA,miRNA)可调控细胞的增殖、分化、凋亡和代谢等生物过程,参与生物的生殖发育过程.作为let-7家族的一员,miR-202具有高度保守的碱基序列,提示miR-202在不同物种中的功能和调控作用可能相似.其可参与多种机体的病理生理过程,如减缓肿瘤细胞的增殖、迁移和侵袭,调控T细胞分化,参与调控神经发育和神经退行性疾病.还可参与配子的发生与成熟,调控生殖生理过程.综述miR-202在精子发生、卵泡发育及生殖内分泌中的调控作用.
Abstract
MicroRNAs(miRNAs)have emerged as key regulators of diverse biological processes,including cell proliferation,differentiation,apoptosis,and metabolism.They are also actively involved in the reproductive and developmental processes of organisms.Among the let-7 family,miR-202 stands out owing to its high conservation across different species,implying the potential shared functions and regulatory roles.Substantial evidence from numerous studies underscores the involvement of miR-202 in a wide range of pathophysiological processes.Notably,it exerts significant inhibitory effects on tumor cell proliferation,migration,and invasion.Moreover,miR-202 plays a critical role in modulating the differentiation of T cell and exhibits the implications in the regulation of neurodevelopment and neurodegenerative diseases.The increasing evidence have indicated that miR-202 plays a crucial role in gamete development and the regulation of reproductive physiology.In this article,we review the regulatory roles of miR-202 in key reproductive processes,namely spermatogenesis,follicle development,and reproductive endocrine regulation.
关键词
微RNAs/精子发生/性分化/生殖细胞/微小RNA-202/生殖调控Key words
MicroRNAs/Spermatogenesis/Sex differentiation/Germ cells/miR-202/Reproductive modulation引用本文复制引用
基金项目
国家自然科学基金(82271734)
国家自然科学基金(82101794)
出版年
2024
国家科技期刊平台
NSTL
万方数据