The Role of Gut Microbiota in Patients with Polycystic Ovary Syndrome
Gastrointestinal microbiome is a rich collection of microorganisms that exist in the human intestine,which affects the life activities of the body via various pathways such as nerve,endocrine,and participates in the process of many diseases.Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorders in reproductive-aged women.Gastrointestinal microbiome may be a potential pathogenic factor for the development of PCOS,and the change of its composition is correlated with clinical features such as insulin resistance,hyperandrogenism,chronic inflammation and obesity.Similarly,the metabolites of gastrointestinal microbiome such as bile acids and short-chain fatty acids are involved in the pathological process of PCOS.In this context,the agents of fecal microbiota transplantation,probiotics,prebiotics and synbiotics,as well as the natural products including alkaloids,flavonoids and polyphenols,can change the composition of gastrointestinal microbiome and the level of metabolites,and regulate the function of gastrointestinal microbiome to improve the endocrine and metabolic diseases of PCOS.Therefore,the research progress on gastrointestinal microbiome is reviewed in order to provide a reference for clinical therapeutic approaches of PCOS.
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