Progress in the Diagnosis and Treatment of Obstetric Antiphospholipid Syndrome
Obstetric antiphospholipid syndrome(OAPS)is an autoimmune disease characterized by persistent positivity of antiphospholipid antibody(aPL)and pathological pregnancy,with clinical manifestations such as recurrent spontaneous abortion,fetal death,fetal growth restriction,preeclampsia,and premature delivery.Early diagnosis and appropriate management of the patients with OAPS can significantly reduce the incidence of pregnancy complications.Currently,the first-line therapeutic option is aspirin combined with low molecular weight heparin,which improves the pregnancy outcome in most patients.The second-line therapeutic medications,such as hydroxychloroquine and glucocorticoid,can be used as a complement to the first-line therapeutic option.The emerging therapeutic medications,such as biologics and statins,are still at the exploratory stage of clinical application.In this article,we review the advances in the diagnosis and treatment of OAPS.
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