The Effect of Time Interval between Hysteroscopic Polypectomy and Start of Frozen-Thawed Embryo Transfer Cycles on Pregnancy Outcomes
Objective:To investigate whether the time interval between hysteroscopic polypectomy and the start of frozen-thawed embryo transfer(FET)cycles affect pregnancy outcomes.Methods:This was a retrospective clinical study conducting FET treatment between January 2021 and July 2023.All patients adopted the freeze-all strategy due to abnormal endometrium condition during in vitro fertilization-embryo transfer(IVF-ET)cycles.Subsequently,they were diagnosed as endometrial polyps and underwent hysteroscopic polypectomy before the first FET.Participants were divided into three groups,based on the time interval between hysteroscopic polypectomy and the start of FET cycle.Group A consisted of women who underwent FET after their next menses(n=303),group B after two menstrual cycles(n=159),and group C after three to six menstrual cycles(n=79).Results:Group C had a similar proportion of cesarean section with Group A,but a significantly higher proportion than Group B(16.5％vs.9.9％vs.6.3％,P=0.045),while other basic parameters were not statistically different among the three groups(P＞0.05).The implantation rate(58.8％vs.48.0％vs.34.1％,P＜0.001)and clinical pregnancy rate(75.5％vs.63.0％vs.50.6％,P＜0.001)in Group B were significantly higher than those in Group A and Group C.The ongoing pregnancy rate in Group B was similar to that in Group A,but significantly higher than that in Group C(67.3％vs.57.1％vs.46.8％,P=0.008).There was no significant difference in early abortion rate among the three groups(P=0.869).After multiple Logistic regression analysis,there was no significant difference in the ongoing pregnancy rate among the three groups(P＞0.05).Conclusions:The FET pregnancy outcomes on the first menstrual cycle after polypectomy are comparable to that of delayed treatment.To alleviate the psychological burden on patients and expedite the time to pregnancy,it is recommended to schedule FET treatment after the first menstrual cycle following polypectomy.
Fertilization in vitroEmbryo transferHysteroscopyPregnancy outcomeFrozen-thawed embryo transferHysteroscopic polypectomy
国家科技期刊平台
NSTL
万方数据
