Advances in CircRNAs Research in Reproductive System
Circular RNAs(circRNAs)are a class of endogenous non-coding RNA(ncRNA)without 5'N7-methylguanosine caps and 3'poly adenylated tails,forming a close loop structure with covalent bonds.Due to the specificity of circRNAs structure,it is highly resistant to ribonucleic acid exonuclease R(RNaseR)and is therefore quite abundant in the cytoplasm.The continuous development of high-throughput sequencing and bioinformatics methods has revealed that circRNAs are highly conserved,stable,disease-specific,and tissue-specific,giving them potential as biomarkers in early clinical diagnosis.Studies have demonstrated that circRNAs interact with oogenesis,ovarian aging,and ovary-related diseases in the female reproductive system,and with spermatogenesis and testicular development in the male reproductive system.CircRNAs are expected to be new diagnostic and therapeutic targets for a variety of reproductive disease.In the paper,we will focus on the biological functions and regulatory roles of circRNAs in reproductive system.
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